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《Journal of Shanghai Jiaotong University(Medical Science)》 2007-01
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Pharmacokinetic profiles of corticosteroid in perilymph and plasma after systemic and transtympanic administration

YANG Jun,WU Hao,HOU Dong-ming,CHEN Jie,ZHANG Ping (Department of Otolaryngology-Head & Neck Surgery,Xinhua Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200092,China)  
Objective To analyse the pharmacokinetic profiles of dexamethasone(DEX) and methylprednisolone(MTH) in perilymph and plasma after intracardiac injection,infusion in otocysts and intratympanic applications with granule gelfoams. Methods The samples of blood and perilymph of scala tympani were obtained at 1-6 h after three ways of administration,and high-performance liquid chromatography was performed to detect the concentrations of MTH and DEX. Results After infusion in otocysts or intratympanic applications with granule gelfoams,the concentrations of DEX or MTH in perilymph were significantly higher than those after systemic administration.The concentrations of DEX in perilymph were significantly higher after intratympanic applications with granule gelfoams than those after infusion in otocysts at every sampling time except 1.33 h,1.67 h and 2 h(P0.01).However,the concentrations of MTH in perilymph were significantly higher after infusion in otocysts than those after intratympanic applications with granule gelfoams at every sampling time except 4 h and 6 h(P0.05). Conclusion By infusion in otocysts or intratympanic applications with granule gelfoams,both MTH and DEX can effectively infuse into scala perilymph through round window membrane and reach the concentrations higher than those after systemic administration.The concentrations of DEX in perilymph are higher after intratympanic applications with granule gelfoams than those after infusion in otocysts,while the concentrations of MTH in perilymph are relatively higher after infusion in otocysts.
【Fund】: 上海市科委基金(034119819)~~
【CateGory Index】: R764
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1 LIN Yunjuan,YU Lisheng (Department of Otolaryngology,People's Hospital, Peking University,Beijing,100044,China);Determination of the dexamethasone in the cochlear tissue after postaurical and intramuscular injection[J];Chinese Archives of Otolaryngology-Head and Neck Surgery;2009-07
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1 SHI Jun YANG Jun WU Hao XUE Bin CHEN XiangpingCAO Rongping MENG Guozhen XIANG Mingliang HUANG Qi(Department of Otolaryngology-Head and Neck Surgery,Xinhua Hospital,Shanghai Jiaotong University,Shanghai,200092,China);Intratympanic dexamethasone medication for suddensen sorineural hearing loss: clinical evaluation[J];Journal of Clinical Otorhinolaryngology;2006-16
【Co-citations】
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1 Deng Cuiping,Lin Haiyan,Ou Yongkan;Nursing for patients with sudden deafness treated by Jiaqiangnong drum injection under ear endoscope[J];Journal of Nurses Training;2008-15
2 Shao Jun,Guo Guang-wei,Su Ji-ping(Department of Otolaryngology and Head and Neck Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China);Methylprednisolone of Intratympanic Injection for Refractory Sudden Sensorineural Hearing Loss[J];Guangxi Medical Journal;2009-06
3 ZHANG Ping~1 WU Hao~1 YANG Jun~1 HOU Dongming~1 ZHANG Shunguo~2 CHEN Jie~1(~1Department of Otorhinolaryngology and Head-neck Surgery,Xinhua Hospital,Shanghai Second Medical University,Shanghai,200092,China;~2Department of Clinical Pharmacology,Xinhua Hospital affiliated Shanghai Second Medical University);Methylprednisolone pharmacokinetics in perilymph and plasma of guinea pig after topical administration and intracardial injection[J];Journal of Clinical Otorhinolaryngology;2005-22
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