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《Journal of Shanghai Jiaotong University(Medical Science)》 2008-02
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Advance in clinical application of methylene blue

CHEN Si-qin reviewer WANG Ying-wei reviser(Department of Anesthesiology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China)  
As an inhibitor of guanylyl cyclase, methylene blue can reduce the production of intracellular cyclic guanosine monophosphate (cGMP), and eventually prevent the relaxation of vascular smooth muscle mediated by excess nitric oxide. Administration of methylene blue is able to increase mean arterial blood pressure and systemic vascular resistance, and reduce the need for vasopressors. Besides, it can enhance myocardial contractility, decrease serum lactate levels, and provide more favorable tissue perfusion. The paper reviews the mechanism and clinical application of the above characteristics of methylene blue.
【CateGory Index】: R96
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【References】
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1 LIU Quan Hong ①** WANG Pan ① LI Meng ① QI Hao ① SHANG Zhi Yuan ② REN Yao Hui ① ZHANG Kun ① YAO Xiao ① (① College of Life Sciences, Shaanxi Normal University, Xi'an 710062, China) (② Institute of Applied Acoustics, Shaanxi Normal University, Xi'an 710062, China);Apopotosis of Ehrlich ascites tumor cells by sonochemical-activated hematoporphyrin[J];Acta Zoologica Sinica;2003-05
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