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《Journal of Shanghai Jiaotong University(Medical Science)》 2008-02
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Advance in clinical application of methylene blue

CHEN Si-qin reviewer WANG Ying-wei reviser(Department of Anesthesiology, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China)  
As an inhibitor of guanylyl cyclase, methylene blue can reduce the production of intracellular cyclic guanosine monophosphate (cGMP), and eventually prevent the relaxation of vascular smooth muscle mediated by excess nitric oxide. Administration of methylene blue is able to increase mean arterial blood pressure and systemic vascular resistance, and reduce the need for vasopressors. Besides, it can enhance myocardial contractility, decrease serum lactate levels, and provide more favorable tissue perfusion. The paper reviews the mechanism and clinical application of the above characteristics of methylene blue.
【CateGory Index】: R96
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Chinese Journal Full-text Database 2 Hits
1 ZHENG Jia-peng,DING Zhen-qi,MENG Jia-rong,LIU Liang-tian.Department of Orthopaedic,175 Hospital of PLA,Zhangzhou,Fujian 363000,China;Experimental study of methylene blue intraarticular injection on knee joint of rabbit[J];Military Medical Journal of Southeast China;2013-03
2 LOU Yong-jun(Department of Chemical Drugs,Zhejiang Institute for Food and Drug Control,Hangzhou 310004,China);Determination of Stability of Related Substances in Methylene Blue by TLC[J];Herald of Medicine;2013-02
Chinese Journal Full-text Database 10 Hits
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4 XU Chuan-shan~(1,2,3),Albert Wing Nang Leung~(2),YANG Qing~(3)(~1Institute of Ultrasound,Chongqing University of Medical Sciences,Chongqing 400010;~2School of Chinese Medicine & Health Care,Chinese University-Tung Wah Community College,Hong Kong;~3Department of Plastic Surgery,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Photodynamic inhibition of pyropheophorbide-a methyl ester in human nasopharyngeal carcinoma cells[J];Acta Academiae Medicinae Militaris Tertiae;2006-14
5 YANG Jin-cheng, JI Xi-qing, LI Chao-long, LIN Jian-hua, LIU Xing-guoDepartment of Hepatobiliary and Vascular Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.;Impact of early-stage hepatic ischemia-reperfusion injury on other organs of rats[J];Journal of First Military Medical University;2004-09
6 ZHANG Bo,CHEN Jia-ping,HU Jian-kun(West China Hospital,Sichuan University,Chengdu 610041,China);The Clinical Study on the Sentinel Lymph Node of Gastric Cancer by Carbon Nanoparticles Suspension Injection[J];West China Medical Journal;2006-03
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10 TANG Zhaohui ,HU Yuanlong ,XIA Suisheng. Department of Surgery, Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030,China;The effect of postoperative early enteral nutrition on cellular immunity and nutritional status for the patients with gastrointestinal carcinoma[J];Journal of Clinical Surgery;2002-01
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 MENG Qing-hui,WANG Zi-heng,WU Wei-hua,et al(Department of General Surgery,The First Clinical College,Harbin Medical University,Harbin 150001,China);Value of fast histological identification about parathyroid without HE staining in thyroid surgery[J];Journal of Harbin Medical University;2010-06
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