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《Journal of Shanghai Jiaotong University(Medical Science)》 2014-04
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Analysis of association between polymorphism of Bcl-2 gene promoter and major depressive disorder and its clinical phenotypes

ZHANG Chen;WU Zhi-guo;HONG Wu;WANG Zuo-wei;HU Ying-yan;CAO Lan;CHEN Jun;WANG Yong;PENG Dai-hui;LIU Xiao-hua;YI Zheng-hui;LU Wei-hong;YUAN Cheng-mei;LI Ze-zhi;YU Shun-ying;WU Yan;FANG Yi-ru;Division of Mood Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine;Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences& Yunnan Province,Kunming Institute of Zoology;Hongkou District Mental Health Center;Department of Neurology,Changhai Hospital,Second Military Medical University;Department of Genetics,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine;  
Objective To investigate the genetic association between the polymorphism of rs2279115 of Bcl-2gene promoter and the major depressive disorder(MDD)and its clinical phenotypes among Chinese Han population.Methods Totally 701 MDD patients(the MDD group)who visited the Division of Mood Disorders of Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine from January,2006 to December,2012 and 725 healthy control subjects(the control group) were chosen for the study.The clinical phenotypes of patients were determined by the 17 items of Hamilton Depression Rating Scale(HAMD).The peripheral blood samples were collected and the DNA was extracted.Rs2279115 was then genotyped by the TaqMan SNP genotyping assay.Results The differences of frequencies of genotypes and alleles of rs2279115between the MDD group and control group were not statistically significant(P0.05).The differences of scores of HAM D,depressive emotion,and general symptom among polymorphous genotypes of rs2279115 were statistically significant(p0.05).The scores of HAMD,depressive emotion,and general symptom of MDD patients with C/C genotype were significantly higher than those of MDD patients with C/A or A/A genotype.Conclusion The rs2279115 of Bcl-2 gene promoter may be relevant to the clinical symptoms of MDD.
【Fund】: 国家自然科学基金(91232719);; “十二五”国家科技支撑项目(2012BAI01B04);; 国家临床重点专科-上海市精神卫生中心(卫生部医政司2011-873)~~
【CateGory Index】: R749.4
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