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《Shanxi Journal of Traditional Chinese Medicine》 2009-08
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Clinical Observation of Yan-shu Injection and GP Chemotherapy on Non-Small Cell Lung Cancer in Advanced Stage

Liu Yong,Wei Zhi,Meng Ling-zhan,et al.(Tumor Department in Chongqing TCM Hospital,Chongqing,400013,China)  
Objective:To observe the clinical effect of Yan-shu injection and GP(gemcitabine and cisplatin)chemotherapy on non-small cell lung cancer in intermediate-advanced stage.Method:84 cases were divided into treatment group(including 44 cases)and control group(including 40 cases)randomly according to number table.The cases in treatment group were treated by GP chemotherapy combined with Yan-shu injection.The treatment course included 21 days.After two treatment courses curative effect was evaluated.Once a two-cycle was completed,the efficacy was evaluated.The cases in control group were treated by GP chemotherapy.Observe the short-term efficacy,changes in quality of life,toxic and adverse side effects and immune function.Result:The recent total remission rate in treatment group was 40.9%,that in control group was 37.5%.There was no significant difference between the two groups(P0.05).Quality of life in treatment group was improved markedly,KPS score enhanced and improvement rate was 63.6% in treatment group and 30.0% in control group.There was significant difference between the two groups(P0.01).But there was no significant difference on toxic and adverse side effects such as nausea,vomiting,diarrhea and calvities,while the comparison of leukopenia between the two groups showed statistically significance(P0.05).Conclusion:Yan-shu injection combined with GP chemotherapy can increase KPS score,reduce hematological noxious property,enhance tolerance to chemotherapy,and improve quality of life.But it can not significantly improve the short-term effect in non-small cell lung cancer in advanced stage
【CateGory Index】: R734.2
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