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《Shanxi Journal of Traditional Chinese Medicine》 2015-04
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Experimental Study of Animal Acute Toxicity and Skin Stimulating by Zhenshi Jiuwei Ointment

CHEN Hong-yan;Hebei Province Hospital of Traditional Chinese Medicine;  
Objective:To reserch animal models ccute toxicity and skin stimulating induced by Zhenshi Jiuwei ointment,and evaluate the safety of the drug. Methods:To applyind Zhenshi Jiuwei ointment on the intact skin and the damaged skin of the rat models,The toxicity and body weight were observed. To applyind zhenshi Jiuwei ointment on the intact skin and the damaged skin of guinea pig models,By self-control of left andright side after single and multiple administration,to observe the skin stimulating reaction on the skin. Results: In acute toxic test,Zhenshi Jiuwei ointment had no acute toxicity to rats;and no significant effect on body weight,compared with control group. In skin stimulatiny test,there were no skin stimulation on the intact skin of guinea pigs,and had no erythema and edema;there had no obvious skin Stimulation on the damaged skin,and the skin stimulation disappeared after 24 h. Conclusion: In a certain dose,Zhenshi Jiuwei ointment has no acute toxicity on the rats,has no skin stimulating on the guinea pigs.
【CateGory Index】: R285.5
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