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《Shanghai Journal of Stomatology》 2019-02
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Locally delivered macrolides as an adjunct to non-surgical periodontal treatment of chronic periodontitis: a meta analysis

LIU Qiu-yue;ZHANG Yi;LI Jing;XIANG Xue-rong;Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences,Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education;  
PURPOSE: The present meta analysis was designed to determine the effects of macrolides group of antibiotics as local drug delivery agents to scaling and root planing(SRP), compared with SRP alone or plus placebo. METHODS:Electronic and manual literature searches were conducted to select randomized controlled trials(RCTs) comparing SRP +macrolides versus SRP alone using the following databases: PubMed, Cochrane Library, Science Direct, EMbase, CNKI,Wanfang database and VIP data until August 2018. Two reviewers independently extracted the data and evaluated the methodological quality of the included studies. RevMan 5.3 was applied for meta analysis. RESULTS: Seven papers were obtained, which included 439 patients with chronic periodontitis.Meta analysis showed that in the two groups, the changes in probing depth(PD)[MD=0.77, 95%CI(0.48-1.05), P0.00001], clinical attachment loss(CAL)[MD=0.74, 95%CI(0.39-1.10), P0.0001],plaque index(PI)[MD=0.30, 95% CI(0.17-0.43), P0.00001],modified sulcus bleeding index(mSBI)[MD=0.23, 95%CI(0.15-0.32), P0.00001]at 3 month and 6 month of PD [MD=1.15, 95%CI(0.41-1.89), P=0.002] were significantly different, the difference of CAL[MD=0.92, 95%CI(0.43-1.40), P=0.0002], PI[MD=0.51, 95%CI(0.07-0.95), P=0.02] and mSBI[MD=0.18, 95%CI(0.07-0.29), P=0.002] was also significant(P0.05). CONCLUSIONS: SRP combined with local macrolides adjuvant treatment for chronic periodontitis is effective in short-term observation.
【Fund】: 重庆市科卫联合医学科研项目(2018ZDXM031);; 重庆高校创新团队建设计划资助项目(CXTDG201602006);; 重庆市高级市级口腔生物医学工程重点实验室资助项目
【CateGory Index】: R781.42
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