THE ANTIVIRAL ACTIVITIES AND INDUCTION OF INTERFERON IN MICE BY CORYNEBACTERIUM PARVUM VACCINES MADE IN CHINA
Chen Hong-shan (陈鸿珊) et al. Institute of Antibiotics, Chinese Academy of Medical Sciences
Two vaccines of Corynebacterium parvum "Shanghai 7705" and "Beijing 7903" were made from strains of C. parvum No. 76-27 and 77-1 separately in China. One single intravenous injection of the vaccine into mice could protect them from toxic death of intravenous infection of influenza virus A3.Jing-fang 75-39, induce serum y-interferon, activate peritoneal phagocytosis and enhance the anti-influenza virus antibody. The optimal, protection time was 24 hrs post-vaccination, not correlated with the peak of serum interferon level at 6 hrs post-vaccination, but was coincided with the peak of peritoneal phagocytosis 24 hrs after vaccination. The intraperitoneal injection of silica before vaccination may render the phagocytosis ineffective and lower the protection against influenza virus infection, but not the induction of serum IF in mice. These results suggested that the protection power of vaccinated mice against influenza virus infection was closely related to the activation of phagocytosis by Corynebacterium parvum vaccine.Intraperitoneal vaccination gave low protection and subcutaneous vaccination none.