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Effect of Monoclonal anti-Mouse Tao Antibody on the ConA InducedLiver Damage in Mice

Li Xiaogang;Wang Tiancai;Tang Wangxian;Li Shaobai;Zhang Wenying;Du Lijing(Institute of Hepatodisease,Tongji Hospital,Tongji Medical University,Wuhan 430030)  
The present study was designed to establish experimental liver injary model byConA in mice and to detect the changes of plasma TNF-α in this model.The resultsshowed that plasma TNF-α was significantly higher in experimental mice than incontrol.The production of TNF-α was significantly reduced in mice pretreated withmonoclonal anti-mouse Tao antibody.It is most likely that liver injury induced byConA are associated with the induction of TNF-α.Monoclonal anti-mouse Tac antibadg have protection on the ConA induced liver injury.
【CateGory Index】: R394
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