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The Effects of Astragalus Saponins on the Induction of TNF with LPSof Vibrio Cholerae in Vitro

Zhang Wenhua;Lin Houyi;Yu Furong;Zhao Fuzhong;You Lifeng;Zhang Yingdi(Nanjing Medical University,Nanjing 210029)  
The effects of Astragalus Saponins(ASI,SK)on the induction of TNF by murineperitoneal macrophage with LPS of Vibrio Cholerae were stuided. Experimental results showed that when ASI or SK 1 ̄10μg/ml)and LPS(1:10)of VC 569B strain wereused to stimulate the peritoneal macrophage of mice,the activity of TNF was 4 ̄5 times higher than that with LPS alone.It was further indicated that murine peritonealmacrophages were activited by Astragalus Saponins,so that it can enhance the induction of TNF with LPS of Vibrio Cholerae.The TNF inducing activity of classicel biotype 569B strain was higher than that of the EITor biotype Wj2 strain.
【CateGory Index】: R967
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