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《Progress In Biochemistry and Biophysics》 2002-01
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Identification and Characterization of a Nasopharyngeal Carcinoma(NPC) Related Gene Which Shows The Hallmark Characteristics of a Processed Pseudogene

XIANG Juan-Juan, YU Ying, WANG Jie-Ru, ZHU Shi-Guo, ZHANG Bi-Cheng, LI Zhong-Hua, LI Gui-Yuan ** (Cancer Research Institute, Xiangya School of Medicine, Central South University,Changsha 410078, China)  
A nasopharyngeal carcinoma(NPC) related gene, named NAG73 which mapped to 3p25~26 was identified by positional candidate cloning. Structural analysis reveals that NAG73 has an intronless genomic sequence, which is homologous with the fourth exon and 3′UTR of Homo sapiens Growth Hormone Secretagogue Precursor Gene (GHRELIN). NAG73 has no 5′ promoter sequence, and has putative polyA. The results suggest that NAG73 might be a processed pseudogene of GHRELIN. It has been showed that NAG73 is actively transcribed in some cells and tissues examined. There is expression difference between normal nasopharynx epithelia and nasopharyngeal carcinoma epithelia. And there is potential for a NAG73 encoded translation product. So, it is possible that NAG73 is translated and the product might act on the tumorigenesis of nasopharyngeal carcinoma.
【Fund】: 国家高技术“863”计划资助项目 (1 0 2 1 0 0 1 0 5);; 国家重点基础研究发展规划项目 (G1 9980 51 0 0 8)~~
【CateGory Index】: R739.63
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