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Oxidative Stress induced Apoptosis

Lu Yi;Pan Huazhen; Xu Caimin (Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China).  
Apoptosis, an active process of cellular self-destruction involved in a variety of physiological and pathological conditions, can be induced by either oxidants or stimulators of cellular oxidative stress. Mild damages such as ionizing and ultraviolet radiation, hyperoxia,hyperthermia, infection etc, will injure the cell via reactive oxygen species (ROS), which may either react with the polyunsaturated fatty acids,leading to the formation of oxidized lipids, or activate certain genes related to cell death. As a result, the cell commits suicide following a sequence of biochemical change. hcl-2, one of the proto-oncogenes, was found to play a role in the regulation of apoptosis.
【Fund】: 国家自然科学基金
【CateGory Index】: R329.25
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