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AN EXPERIMENTAL STUDY ON THE PREVENTION AND THERAPY OF POST-MENOPAUSE WITH CHINESE DRUGS

Song Xianwent Shi Yingu, Sheng Peizhi,et al.Department of Traditional Chinese Orthopedics and Traumarology,Ganquan Hospital. Shanghai Railway Medical College  
The study evaluated the effects of Chinese drugs on post-menopause osteoporisis rat models by measuring bone mineral contents and bone strengths in femur. Twelve months female S. D rats were ovariectomized. After 3 months, the results demonstrated that ovariectomy reduced the bone mineral contents and bone strength in femur significantly (P0. 01). It was suggested that the models of post-menopause osteoporosis had alreadly occured. Then, the models were treated with stilbestrol or Chinese drugs for 3 months , it was found that the femur bone mineral contents and bone strength progressively decrease in ovariectomized rats without treatment, in contrast, the femur bone mineral contents and bone strengths didn't decrease in rats treated with stilbostrol or Chinese drugs. But ,the bone mineral contents and bone strength were not reversed to the normal levels. The study demonstrated that the rat models of post-menopause were prevented and treated effectively with Chinese drugs.
【Key Words】: Chinese drugs Osteoporosis Bone mineral contents Bone biomechanics Rats
【CateGory Index】: R259
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1 SONG Xian wen 1,SHEN Pei zhi 2,CHEN Bai xian 1 (1 Dept.of Chinese Traditional Bone Injury,Tongji Hospital,Tongji Univesity,Shanghai 200065,China; 2 Research Section of Bone Injury,Shanghai Traditional Medical Research Institution,Shanghai 200032;Clinical Observation on Treatment of Post-Menopausal Osteoporosis with Traditional Chinese Herbs and Exploration of its Mechanism[J];Journal of Shanghai Tiedao University;2000-11
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