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Comparison of NPC Transforming Gene Tx to Ig Kappa Constant Region Gene and Their Expressions in Different Cell Lines

HU Wei-Xin; CAO Ya; LI Xiao-Yan;LEO M.Lee and YAO Kai-Tai(Cancer Research Institute,Hunan Medical University,Changsha 410078,FCRDC-NCI,Frederick,Maryland 21702,USA)  
We have compared the nucleotide sequence and amino acid sequence of coding product of human immunoglobulin light chain kappa constant region gene(IGKC) to those of human nasopharyngeal carcinoma(NPO) transforming gene(Tx gene)2.8kb EcoR I fragment.The results show that the homology of these two genes is as high as 99.5% and 100 % in coding region, indicating that Tx gene and kappa gene are the same gene.This conclusion is also supported by restriction mapping and Southern blot analysis of the two genes. Meanwhile, the expressions of Tx gene and kappa gene in different malignant cell lines have been investigated. Interestingly,the kappa gene is not only expressed in B lymphatic cell lines(RAji,B95-8, BJAB),but also expressed in NPO cell lines(CNE2,CNE1,HNE1).The expression of this gene has not been detected in human T lymphatic cell lines(Hut 102,MT 2) and in human cervical cell lines(HT-3,ME-180,Hela).The relationship between the expression of kappa gene and NPC carcinogenesis is being investigated.
【CateGory Index】: Q786
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