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《Journal of Shanghai Medica(University)》 1986-01
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IMMUNOMODULATORY ACTION OF BUPLEURUM KUNMINGENSE POLYSACCHARIDE ON LYMPHOCYTE PROLIFERATION

ZHANG LUOXIU, PAN SHENGLI, HUANG KAIXIAN, GU KEXIAN(Departments of Pharmacology and Pharmacognosy, Faculty of Pharmacy, Shanghai Medical University, Shanghai)  
Bupleurum kunmingense polysaccharide (BKP) was isolated from Bupleurum kunmingense Y. Li et S. L. Pan sp nov. The effects of BKP on the proliferative response of mouse splenocytes to mitogens as measured by 3H-dT incorporation are reported. BKP at 100μg/ml was effective in promoting proliferation of C57BL/6 mouse splenocytes incubated with Con A (2.5μg/ml) for 48 hours. At this concentration BKP also increased the response of mouse splenocytes to various other mitogens including PHA, LPS and PWM. These results suggest that BKP might be developed as an immunomodulator.
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