Correlaction Study Between Expression of HER-2/neu in Ovarian Carcinoma Cells and T-cell Infiltration in vivo on Ovarian Tumors
ZHU Zhi-ling,LI Da-jin,HUANG Min-li(Obstetric and Gynecologic Hospital,Fudan University,Shanghai 200011,China)
Purpose To determine the correlation between expression of proto-oncogene HER-2/neu on ovarian tumor cells and T-cell infiltration in vivo ovarian tumor micro-environment. Methods Thirty three samples of primary epithelial ovarian can cers were analysed with flow cytometry for proto-oncogene HER-2/neu expression.Immunohistochemical analysis was performed using monoclonal antibodies that recognize leukocyte differentiation antigens (LCA,CD 3) on cryostat sections of prinmary epithelial ovarian cancinoma.The results were compared with the expression of proto-oncogene HER-2/neu expression.which provises the statue of micro-environment in ovarian carcinoma patients which have overexpression of proto-oncogene HER-2/neu. Results Close correlation were revealed between the expression of proto-oncogene HER-2/neu and the numbers of infiltrating LCA positive cells (r=-0.680,P=0.000 1) and CD+ 3 cells (r=-0.552 39,P=0.000 1). Conclusions The study revealed that expression of proto-oncogene HER-2/neu has some inherent correlation with the status of human immunity in tumor micro-environment on ovarian carcinoma.
【CateGory Index】： R737.31