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《Journal of Shanghai Medica(University)》 2003-05
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The Effects of β-elemene on Caspase Activity and Expression of Survivin and Apoptosis of Human Gastric Carcinoma SGC-7901 Cell

GUAN Wen-ming,FAN Yu△,GUO Xue-liang△,LIN Geng-jin△,QIAN Li-ping△,XU Zu-de △△,LI Hua △△(Department of Internal Medicine,Second Hospital,Luohe,Henan Province,462000; △Department of Gastroenterology,Huashan Hospital,Fudan University,Shanghai 200040, △△Department of Pathology,Shanghai Medical Science,Fudan University,Shanghai 200032,China)  
Purpose To study the expression of Survivn and Caspase activity of human gastric carcinoma cell line SGC-7901 treated with β-elemene,and to investigate the mechanism of β-elemene to induce tumor cell's apoptosis. Methods After gastric cancer SGC-7901 cell were treated with different doses β-elemene,the protein and mRNA level of Survivn were detected by Western blot as well as Northern blot respectively,Caspase activity were evaluated by microplate reader,apoptosis were studied by TUNEL. Results β-elemene could down-regulate the level of protein and mRNA of Survivn,and elevate the Caspase activity,and induce gastric cancer SGC-7901 cell apoptosis.The effects were be relevant to the time and dose of β-elemene. Conclusions β-elemene could induce SGC-7901 cells apoptosis by down-regulation of expression of Survivin and up-regulation of Caspase activity.
【CateGory Index】: R735.2
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