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《Journal of Shanghai Medica(University)》 2005-02
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Effects of Etomidate on Calcium Channel Subtypes on Cerebrocortical Synaptosomes

ZHANG Jun,ZHUANG Xin-liang,LI Shi-tong,WANG Yin-tian (Department of Anesthesiology,Huashan Hospital,Fudan University,Shanghai 200040; △Department of Anesthesiology,Shanghai First People's Hospital,Shanghai Jiaotong University,Shanghai 200080,China)  
Purpose To study the effects of etomidate on calcium channel subtypes on rat cerebrocortical synaptosomes. Methods By using freshly isolated SD rat cerebrocortical synaptosomes and KCl as chemical stimulant to depolarize,we investigated the effects of etomidate with or without calcium channel antagonists on KCl-induced increased intrasynaptosomal calcium concentrations with spectrofluorometer. Results The P-type (maybe including Q-type) calcium channel accounts for 50% calcium influx into synaptosomes,N-type for about 20%,while L-type didn't change KCl-induced increased intrasynaptosomal calcium concentrations.P/Q-type cal-cium channel antagonist ω-agatoxin IVA had no different effects on increased intrasynaptosomal calcium concentrations with or without 100 μmol/L etomidate,but for N- or L-type cal-cium channel antagonist,it had additional effects when with etomidate. Conclusions P-and N-type calcium channels played a primary role in calcium ion influx into nerve terminals when depolarization.And P/Q-type channels maybe involved in inhibitory effects of etomidate on KCl-induced increased intrasynaptosomal cal-cium concentrations.
【CateGory Index】: R96
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