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《Journal of Shanghai Medica(University)》 2005-02
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Effects of Etomidate on Calcium Channel Subtypes on Cerebrocortical Synaptosomes

ZHANG Jun,ZHUANG Xin-liang,LI Shi-tong,WANG Yin-tian (Department of Anesthesiology,Huashan Hospital,Fudan University,Shanghai 200040; △Department of Anesthesiology,Shanghai First People's Hospital,Shanghai Jiaotong University,Shanghai 200080,China)  
Purpose To study the effects of etomidate on calcium channel subtypes on rat cerebrocortical synaptosomes. Methods By using freshly isolated SD rat cerebrocortical synaptosomes and KCl as chemical stimulant to depolarize,we investigated the effects of etomidate with or without calcium channel antagonists on KCl-induced increased intrasynaptosomal calcium concentrations with spectrofluorometer. Results The P-type (maybe including Q-type) calcium channel accounts for 50% calcium influx into synaptosomes,N-type for about 20%,while L-type didn't change KCl-induced increased intrasynaptosomal calcium concentrations.P/Q-type cal-cium channel antagonist ω-agatoxin IVA had no different effects on increased intrasynaptosomal calcium concentrations with or without 100 μmol/L etomidate,but for N- or L-type cal-cium channel antagonist,it had additional effects when with etomidate. Conclusions P-and N-type calcium channels played a primary role in calcium ion influx into nerve terminals when depolarization.And P/Q-type channels maybe involved in inhibitory effects of etomidate on KCl-induced increased intrasynaptosomal cal-cium concentrations.
【CateGory Index】: R96
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【References】
Chinese Journal Full-text Database 2 Hits
1 LI Xiu-hua,GAO Er,ZHANG Yan.(Department of Anesthesiology,Wei Fang Medical College,Wei Fang 261042,China);Experimental and Clinical Research of Etomidate fat Emulsion[J];Medical Recapitulate;2006-24
2 SHI Xing-xing1,YIN Bai-shuang1,2,LI Xiao-bo1,LI Zhi-qiang1,WANG Hong-bin1(1.College of Animal Medicine,Northeast Agricultural University,Harbin 150030,China; 2.Department of Animal medicine,Jilin Agriculture science and technology College,Jilin 132101,China);Effects of Tiletamine-Zolazepam on calcium kinetics of synaptosomes in rat cerebral cortex[J];Chinese Journal of Veterinary Medicine;2013-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 YU Yao-Qing, CHEN Jun. Institute for Biomedical Sciences of Pain, Fou rth Military Medical University, Xi'an 710032, China;Structure and classification of voltage-gated potassium,calcium and sodium channels[J];Chinese Journal of Neuromedicine;2005-05
2 WANG Yang, WANG Da-yong. Department of Genetics and Developmental Biology, Base Medical College, Southeast University, Nanjing 210009, China;Molecular mechanism of neurotransmitter release[J];Chinese Journal of Neuromedicine;2005-09
3 XIE Yan, YU Zheng ping, ZHU Guang xu, FANG Qiang, JIANG Hai hong (Department of Labour Hygiene, Third Military Medical Universiry, Chongqing 400038,China);Mechanisms of morphine-evoked changes of intracellular calcium in primary cultured hippocampal neuronal cells[J];Acta Academiae Medicine Militaris Tertiae;2002-02
4 SHE Ruiping (College of Animal Medicine, China Agricultural University,Beijing,100094,China);Outline of Diffuse Neuroendocrine System[J];Progress In Veterinary Medicine;2003-01
5 HAO Xiao-Hua1,ZHANG Guo-Zeng2( 1.Department of Life Sciences,Hunan Art and Science College,Changde 415000,China;2.Department of Life Sciences,Henan University,Kaifeng 475000,China );Recombinant aequorin luminous protein and its application in measuring calcium signal of plant cell[J];Guihaia;2009-04
6 PANG Chong 1,2,WU Ning 1,LI Jin 1(1.Department of New Drug Evaluation,Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences, Beijing 100850,China;2.School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,China);N-type voltage-dependent calcium channel blockers on analgesia:research advances[J];Journal of International Pharmaceutical Research;2012-06
7 LI Jun-min~1, LIU Zhao-hui~2, SHANG Zhong-lin~3(1.The 3rd Hospital of Hebei Medical University,Hebei Shijiazhuang 050051,China;2.Department of Basic Medical Science,Chengde Medical College,Hebei Chengde 067000,China;3.College of Life Science,Hebei Normal University,Hebei Shijiazhuang 050016,China);The Ion Channels in Cell Membrane[J];;2005-05
8 HAN Xueping, ZHOU Zhigang, MA JunzhiDepartment of Anesthesiology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052;Effects of etomidate total intravenous anesthesia on serum cortisol in patients undergoing gastric carcinoma radical operations during perioperative period[J];Journal of Zhengzhou University(Medical Sciences);2006-02
9 Guo Yi 1 Ren Zhaoyu 2 Hou Xun 1,2 (1.Institute of Photonics & Photon-Technology and Provincial Key Laboratory of Photoelectronic Technology,Northwest University,Xi'an 710069) (2.State Key Laboratory of Transient Optics and Technology,Xi'an Institute of Optics and Precision Mechanics,Chinese Academy of Sciences,Xi'an 710068);Fluorescence methods for analyzing intracellular second messenger-calcium Ion[J];Laser Journal;2003-01
10 YING Yang-jun+{1,2}, HUANG Zu-qia+1 (1^Institute of Low Energy Nuclear Physics,Beijing Normal University,Beijing 100875,P R China;2^Institute of Applied Physics and Computational Mathematics,Beijing 100088,P R China) [;FREQUENCY RESPONSE OF CELL CALCIUM OSCILLATION AND SYNCHRONIZATION[J];Chinese Journal of Computation Physics;2001-05
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