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《Fudan University Journal of Medical Sciences》 2018-01
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Serum miRNA-767-3p level in patients with colorectal cancer and its diagnostic value

CHEN Yu-zhuo;LIU Hai-ning;LIU Tao-tao;Department of Gastroenterology,Zhongshan Hospital,Fudan University;  
Objective To assess potential diagnostic value of miRNA-767-3p in colorectal cancer(CRC). Methods The serum miRNA-767-3p levels in CRC patients,colorectal adenoma patients and healthy people were determined using real time quantitative PCR(qRT-PCR).The concentration of carcino embryonic antigen(CEA)was detected via chemiluminescent immunoassay(CLIA)in above three groups.Receiver operating curves(ROC)were established to evaluate the diagnostic efficiencies of miRNA-767-3p and combination with CEA in CRC patients. Results The levels of miRNA-767-3p were declined in CRC patients,colorectal adenoma patients and healthy people,respectively.ROC curves illustrated that the area under ROC curve(AUC)of miRNA-767-3p was up to 0.770(95%CI:0.698-0.842),with sensitivity of 80% and the specificity of 68% in CRC diagnosis.Moreover,a higher AUC up to 0.862(95%CI:0.806-0.918)with the sensitivity of 73% and the specificity of84% was achieved when miRNA-767-3p and CEA were combined. Conclusions Serum miRNA-767-3p could be considered as an independent diagnostic marker of CRC,and miRNA-767-3p combined with CEA would increase the detective quantum efficiency of CRC.
【CateGory Index】: R735.34
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