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THE EFFECT OF -SELENOCARRAGEENAN ON SPATIAL DISCRIMINATION LEARNING IN MICE WITH EXPERIMENTAL COGNITIVE IMPAIRMENT

Wang Jing;Qiu Quanqing; Jiang Minghua(Department of Pharmacology, School of Pharmacy,Shanghai Medical University,Shanghai)  
By using the Y-maze method,the effect of -selenocarrageenan(μ-SeC) on spatial discrimination learning and memory retention in mice were studied.The results were as follows:①-SeC(po 180 or 108 mg/kg, qd×14d) given before testing raised discrimination learning ability in mice;②-SeC(po 180, 108 or 64.8mg/kg,qd×14d) improved the discrimination learning impairment induced by scopolamine(ip 4 mg/kg);③-SeC(po 180 mg/kg, qd×14d) improved the memory retention impairment indnced by scopolamine. It was shown that SeC exerted the improved effects on the experimental cognitive impairment in mice.
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