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Immunological effects of ursolic acid from hawthorn fruits on hepatocellular carcinoma HepS cell in mice

LIN Ke,ZHANG Tai-ping,ZHU Shun,WU Chen,ZHANG He-yun(State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Nanjing University,Nanjing 210093,China)  
Purpose To explore the protective effect of ursolic acid from hawthorn fruits to immunosuppressive mice caused by cyclophosphamide(CTX) and the effect of UA on hepatocellular carcinoma HepS cell.Methods Immunosuppressive model with CTX by ip was established.The influence of UA in immunological function on model mice was observed.The effect of UA on the cell apoptosis of HepS tumor cell was assessed by flow cytometrial analysis and DNA agarose gel electrophoresis.Results Every UA group could significantly increase the peripheral leucocyte count and enforce phagocytic activity of peritoneal macrophage.But as far as enhancing the proliferation of spleen lymphocyte and increasing spleen index as concerned,UA groups at four different dose levels can improve the rate of apoptosis.Conclusion UA displayed obviously positive regulation in immunosuppressive mice and improved the apoptosis of hepatocellular carcinoma HepS cell.
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