Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Biochemical Pharmaceutics》 2008-03
Add to Favorite Get Latest Update

Protective effects of Gynostemma Pentaphyllum polysaccharide on CCl_4-induced liver injury in mice

XIAO Zeng-ping1,JI Ai-guo1,2,SONG Shu-liang2,LIANG Hao2,LIU Ying-ying3 (1.School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China;2.SDU-Weihai International Biotechnology R&D Center,Weihai 264209,China;3.Ocean School of Shandong University at Weihai,Weihai 264209,China)  
Purpose To separate and to purify polysaccharide from Gynostemma Pentaphyllum,and to study the protective effect on CCl4-induced liver injury in mice.Methods After deproteinization,despectin,discoloration and ultrafiltration we obtained the purified Gynostemma Pentaphyllum polysaccharide.The mice were treated with purified Gynostemma Pentaphyllum polysaccharide via intragastric administration for 7 days before 0.5% CCl4 in arachis oil treatment.After another twice administration,the activities of serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST),reduced glutathione hormone(GSH)and malondialdehyde(MDA),as well as the pathological changes of the liver were determined in all groups.Results All doses remarkably inhibited the rising of serum ALT and AST,and decreased the content of MDA in hepatic tissues,meanwhile increased the activities of GSH in hepatic tissues.The pathological changes were also significantly improved in the mice of treating groups.Conclusion Gynostemma Pentaphyllum polysaccharide had protective effects on CCl4-induced acute liver injury in mice.
【Fund】: 威海市大学共建项目(编号:0000413420615)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 SU Hui , ZHANG Pei-jian, JIN Cheng (Faculty of General Surgery, The Second Hospital Affiliated to Yangzhou University, Yangzhou 225001, Jiangsu, China);Anti-hepatocarcinoma effect of polysaccharides:An update[J];Journal of Medical Postgraduates;2010-04
2 SONG Shu-liang1,XIAO Zeng-ping1,2,JI Ai-guo1,2,LIANG Hao1,WANG Wei-li1,WANG Yun-shan1(1.SDU-Weihai International Biotechnology R&D Center,Weihai 264209,China;2.School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China);Protective effect of Gynostemma Pentaphyllum polysaccharide on alcohol-induced injury of HepG_2 cell[J];Chinese Journal of Biochemical Pharmaceutics;2008-05
【Citations】
Chinese Journal Full-text Database 1 Hits
1 SONG Shu-liang 1,2,TANG Jin-bao3,JI Ai-guo 1,2, LIANG Hao2, ZHU Peng1, WANG Wei-li2 (1.Pharmacy College of Shandong University, Jinan 250012, China; 2. Weihai International Biotechnology R & D Center, Weihai 264209, China; 3. Pharmacy Department of Weifang Medical College, Weifang 261042, China);The Extraction, Purification and Assaying of Gynostemma pentaphyllum Polysaccharides[J];Journal of Chinese Medicinal Materials;2006-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LENG Gui-hua (School of Chemistry and Biological Engineering,Yichun College,Yichun,Jiangxi 336000);Comparison on Content of Baicalin between Radix scutellariae and Its Extractive Drug Residue[J];Journal of Anhui Agricultural Sciences;2007-10
2 LIU Xin-yan et al (School of Life Science,Nantong University,Nantong,Jiangsu 226007);Study on Effective Components Extraction and Antioxidant Capacities of Gynostemma pentaphyllum Makino[J];Journal of Anhui Agricultural Sciences;2008-31
3 Zhang Xiuli\ \ Tan Huarong\ \ Hu Yinghui (Anhui Agricultural University, 230036, Hefei, Anhui, PRC) Zheng Lin (Yaoluoping National Nature Reserve, 242601, Yuexi, Anhui, PRC);NUTRITIONAL COMPONENTS OF GYNOSTEMMA LAXUM (WALL.) CONG. FROM ANHUI PROVINCE[J];Journal of Anhui Normal University(Natural Science);1997-03
4 Yang Caixia;Wang Dawei;Zhu Ping( Baoji School of Traditional Chinese Medicine, Baoji 721007;Dept. Chem., Weinan Teachers' Coll., Weinan 714000;Dept. Chem. &. Chem. Eng., Baoji Coll. Arts & Sci., Baoji 721007);TSUNEMATSU TAKEMOTO AND GYNOSTEMMA PENTAPHYLLUM[J];Journal of Baoji College of Arts and Science(Natural Science Edition);1997-04
5 CHEN Xin,ZHANG Mei,TANG Pei-ran,et al(Chengdu University of Traditional Chinese Medicine,Chengdu,610075,China);Protective Effect of Herpetospermum Caudigerum Extracts on Liver Injury Induced by Carbon Tetrachloride in Mice[J];Journal of Chengdu University of Traditional Chinese Medicine;2008-03
6 LIU Guo-chen1,LI Sheng-yu2,HE Da-jun2,ZHAO Xue-song2,SUN Fang2,ZHOU Yi-fa2(1.Chaoyang Teachers' College,Chaoyang 122000,China;2.School of Life Sciences,Northeast Normal University,Changchun 130024,China);Selectively acidic hydrolysis of steroidal saponins[J];Journal of Northeast Normal University(Natural Science Edition);2007-02
7 LIU Yan, LI Tian-jiao, ZHAO Jin-yan, et al (Department of Integrative Medicine, FUTCM, Fuzhou, Fujian 350108, China);Effect of Polysaccharide from Rubus Alceaefolius Poir on Drug-metabolizing Enzyme in Acute Liver Injury Rat[J];Journal of Fujian University of Traditional Chinese Medicine;2008-02
8 Yu Dequan (Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050, China)[;Prospect in Creating New Drugs from Chinese Herbal Medicine[J];Engineering Science;1999-02
9 LIU Pinggui1,WANG Yilin2(1.Jiufang Middle School,Zhuzhou 412001,China;2.College of Chemistry and Chemical Engineering of Guangxi University,Nanning 530004,China);Determination of the Content of 4 Trace Elements in Gynositemma pentaphyllum Makino by Microwave Digestion-ICP-AES[J];Guangdong Trace Elements Science;2008-04
10 Xin LIU 1, Rong Min YU2, Wen Luan HSIAO 3, Shou Xun ZHAO 1, Wen Cai YE 1 * 1 Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009 2 School of Pharmacy, Jinan University, Guangzhou 510632 3 Department of Biology, The Hong Kong University of Science and Technology, Hong Kong;Three New Dammarane Glycosides from Gynostemma pentaphyllum[J];中国化学快报(英文版);2004-01
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Chen Qianfen;Tian Hecun;Zhang Chenyin;Chu Dekai;Yang Weidong(Department of Pathophysilolgy,Bengbu Medical College,Anhui 233003);Protective effect of gypenosides on global cerebral ischemia-reperfusion injury in rat[J];ACTA ACADEMIAE MEDICINAE BENGBU;1996-06
2 TANG Xiao-jun, CHI Jian-wei, ZHANG Ming-wei, ZHANG Yan, LI Jian-xiong, WEI Zhen-cheng, ZHANG Rui-fen(Agro-biotech Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Food, Ministry of Agriculture, Guangzhou 510640, China);EXTRACTION CONDITIONS AND CONTENT DETERMINATION OF POLYSACCHARIDE IN LITCHI FRUITS[J];Journal of South China Normal University(Natural Science);2005-02
3 Liao Li,Zhang Yukuai,Wang Kegeng (Department of Parasitology,Hengyang Medical College,Hengyang, 421001);Studies on Experiment of Gypenosides Decreasing Fiberosis in the Liver Tissue of Schistosoma Japonicum Infected Mice[J];JOURNAL OF HENGYANG MEDICAL COLLEGE;1998-02
4 ZHANG Xiu-mei, CAO Xiao-qing,WEI Xin-bing,et al (Dept. of Pharmacology,School of Medicine, Shandong University);Antioxidant effects of gypenosides on focal brain ischemia-reperfusion injury in rats[J];Acta Academiae Medicinae Shandong;2002-01
5 Zhang Fang, Li Shentian (The Affiliated Hospital of Shandong Medical University);PROTECTIVE EFFECT OF GYPENOSIDES ON LEFT VENTRICULAR CONSTRICTION IN RATS WITH EXPERIMENTAL MYOCARDIAL ISCHEMIA[J];ACTA ACADEMIAE MEDICINAE SHANDONG;1999-01
6 Li Le (Department of Pharmacology, School of Pharmacy, Shanghai Medical University, Shanghai 200032);NEGATIVE INOTROPIC EFFECT OF TOTAL FIAVEOS OF GYNOSTEMMA PENTAPHYLLUM MAK ON ISOLATED GUINEA PIG MYOCARDIUM[J];JOURNAL OF SHANGHAI MEDICA(UNIVERSITY);1998-06
7 WEI Deng-ming 1, YU Jian 1, SONG Qi 1, SUN An-sheng 1, RAO Guang-xun 2 (1.Department of Pathology, Zunyi Medical College, Guizhou 563003, China; 2.Department of Pathology, Tongji Medical College of Huazhong University of Science and Technology, Wuh;Protective Effect of Gypenosides on Experimental Hepatic Fibrosis in Rats[J];LiShiZhen Medicine and Materia Medica Research;2002-05
8 Hu Baochum; Zhang Jintao; Li Xiaoqing and Zeng Mingxin.(Department of Gastroenterology,Guangdong ProvincialCorps Hospital,Chinese People's Armed Police Forces,Guangzhou 510507, China);Effect of gypenosides on nitric oxide and reduced glutathione in injured mouse liver[J];MEDICAL JOURNAL OF THE CHINESE PEOPLE'S ARMED POLICE FORCES;1999-02
9 Sun Wansen;Qiao Chenglin;Liu Rui et al(Department of Traditional Chinese Medicine,Second Clinical Medical College);EXPERIMENTAL STUDY OF GYPENOSIDE ON PREVENTING CHRONIC RENAL FAILURE[J];JOURNAL OF XI'AN MEDICAL UNIVERSITY(CHINESE);1998-02
10 Di Ling, Sun Wansen, Wu Xili, Qiao Chenglin (Department of Integrated Chinese and Western Medicine, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China);Effect of gypenoside on the erythropoietin in rats with chronic renal anemia[J];Journal of Xi'an Medical University(Chinese);2003-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved