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《Chinese Journal of Biochemical Pharmaceutics》 2008-03
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Protective effects of Gynostemma Pentaphyllum polysaccharide on CCl_4-induced liver injury in mice

XIAO Zeng-ping1,JI Ai-guo1,2,SONG Shu-liang2,LIANG Hao2,LIU Ying-ying3 (1.School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China;2.SDU-Weihai International Biotechnology R&D Center,Weihai 264209,China;3.Ocean School of Shandong University at Weihai,Weihai 264209,China)  
Purpose To separate and to purify polysaccharide from Gynostemma Pentaphyllum,and to study the protective effect on CCl4-induced liver injury in mice.Methods After deproteinization,despectin,discoloration and ultrafiltration we obtained the purified Gynostemma Pentaphyllum polysaccharide.The mice were treated with purified Gynostemma Pentaphyllum polysaccharide via intragastric administration for 7 days before 0.5% CCl4 in arachis oil treatment.After another twice administration,the activities of serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST),reduced glutathione hormone(GSH)and malondialdehyde(MDA),as well as the pathological changes of the liver were determined in all groups.Results All doses remarkably inhibited the rising of serum ALT and AST,and decreased the content of MDA in hepatic tissues,meanwhile increased the activities of GSH in hepatic tissues.The pathological changes were also significantly improved in the mice of treating groups.Conclusion Gynostemma Pentaphyllum polysaccharide had protective effects on CCl4-induced acute liver injury in mice.
【Fund】: 威海市大学共建项目(编号:0000413420615)
【CateGory Index】: R285.5
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