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《Shanghai Medical Journal》 2001-02
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Study on P selectin and intercellular adhesive molecule 1 in renal ischemia reperfusion injury

ZHOU Tong, LI Xiao, SONG Wei, et al. Shanghai Second Medical University Ruijin Hospital, Shanghai 200025  
Objective To investigate the role of P selectin and intercellular adhesive molecule 1(ICAM 1) in renal ischemia reperfusion injury, as well as the preventive effect of anti P selectin monoclonal antibody (mAb). Method P selectin and ICAM 1 expression in renal tissue, cell apoptosis, MDA contents and SOD activities were detected in rat model of renal ischemia reperfusion injury. Some ischemia reperfusion rats were treated with anti P selectin mAb. Results Histopathologic damage, up regulated expression of P selectin and ICAM 1, cell apoptosis, increased MDA contents and declined SOD activities were found in renal tissues following renal ischemia reperfusion injury, while these changes became less conspicuous in animal treated with anti P selectin mAb. Conclusion P selectin and ICAM 1 might mediate inflammatory cell infiltration, cell apoptosis and lipid peroxidation and contribute to renal ischemia reperfusion injury, which could be inhibited by the anti P selectin mAb. (Shanghai Med J, 2001,24∶85 88)
【Fund】: 卫生部科研基金! ( 98 2 2 83 );; 上海市自然科学基金! ( 98ZB14 0 2 5 )
【CateGory Index】: R692.9
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