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《Shanghai Medical Journal》 2003-07
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Influence of pyrexia on cognitive function associated with cerebral infarction

XU Xiaoyun, HU Hui, ZHU Wenxia. Department of Neurology, East Hospital, Shanghai Tongji University, Shanghai 200120, China  
Objective To appraise the influence of pyrexia on cognitive function associated with cerebral infarction.Methods In a prospective cohort of 101 patients with acute cerebral infarction, the body temperature within 48 hours of onset(≤37.5℃) was eategorized as normothermia and(≥37.5℃) as hyperthermia. The cognitive functions were evaluated by HDS R three weeks and 6 months after onset respectively. Cognitive changes were compared among the two groups. The relative factors including age, education, infection, neurologic deficit, size of infarction and leukoaraiosis(LA) were evaluated.Results Of the 101 cases of cerebral infarction, hyperthermia was present in 30 cases(29.7%). The cognitive impairments of hyperthermia group and normothermia group were 86.6%(26/30) and 63.3%(45/71) respectively three weeks after the disease onset( P 0.05 ); whereas that in the hyperthermia and normothermia groups 6 months after the onset were 63.3%(19/30) and 40.8%(29/17) respectively ( P 0.05 ). There were no significant differences present in factors such as education, neurologic deficit score and size of infarction except in the factors of age and leukoaraiosis (LA) ( P 0.01 ).Conclusion Pyrexia after acute cerebral infarction is an independent risk factor of cognitive impairment during both acute and convalescent periods. The influence of pyrexia on cognitive function associated cerebral infarction shows no correlation with infection, but significant correlation with age and LA.
【CateGory Index】: R743.33
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