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《Shanghai Medical Journal》 2005-09
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Effect of Schisandrone on [Ca~(2+)]_i induced by amyloid-beta protein in cultured hippocampal neurons

ZHU Jiaqi,TUO Xiping,JIA Liyan,ZHOU Jun.Department of Geriatrics,Changhai Hospital,Second Military Medical University, Shanghai 200433,China  
Objective To observe the effect of Schisandrone on [Ca~(2+)]_i induced by amyloid-beta protein in cultured hippocampal neurons of SD rats.Methods The hippocampal neurons of one-day-old SD rats primarily cultured for seven days were randomly placed in A,B and C dishes.Then the neurons were treated with 1 μmol/L Aβ_(25-35) or 1 μmol/L Aβ_(25-35) and 100 μmol/L Schisandrone or with B27 only for two days.On the ninth day,all neurons of every dish were marked with Fura-2/AM,and the well-marked and dispersed ones were selected for detection and analysed by Metermorph and Metaflour software.The ratio of 340 nm to 380 nm represented the concentration of intracellular free calcium.Results The ratios of neurons in dish A,B and C were 0.5951(±0.0311),0.4168±0.0468 and 0.3617±0.0197 respectively.The ratios of neurons in dish B treated by 1 μmol/L Aβ_(25-35) and 100 μmol/L Schisandrone were higher than the one in dish C treated by B27 only(P0.05),but was lower than the one in dish A treated by Aβ_(25-35)(P0.05).Conclusions Schisandrone can maintain intracellular calcium homeostasis through inhibition of increase of [Ca~(2+)]_i induced by beta-amyloid protein,so as to provide protection of the neurons.
【CateGory Index】: R285;
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