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《Shanghai Medical Journal》 2009-02
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Allogeneic peripheral blood hematopoietic stem cell transplantation for severe aplastic anemia

ZHANG Weiping,FU Li,WANG Jianmin,HOU Jun,SONG Xianmin,ZHOU Hong. Department of Hematology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China  
Objective To evaluate the efficacy of allogeneic peripheral blood hematopoietic stem cell transplantation (allo-PBSCT) for severe aplastic anemia (SAA). Methods Ten patients with SAA (three were diagnosed as SAA-Ⅰand seven as SAA-Ⅱ,with two complicated with severe infection) received allo-HSCT,including eight receiving from related and two from unrelated donors. The patients included five men and five women,with a median age of 27 years old (range:18-42). Most of patients in our group were treated with CsA and other treatments but were all proven to be ineffective before transplant. The period from diagnosis to transplantation was 1-240 months,with a median time of 12 months. PBSC were mobilized with G-CSF for 5 days. Conditioning regimens included ATG-Fresenius 4-5 μg·kg-1·d-1×4 d plus CTX 60 mg·kg-1·d-1×2 d. CsA and MTX were given to prevent acute graft-versus-host disease (aGVHD). The effectiveness and complications were analyzed retrospectively. Results Hematopoiesis reconstitution was achieved in 9 patients and graft rejection occurred in 1 patient.The median periods for neutrophils to reach 0.5×109/L and platelets to reach 20×109/L were 13.2 (11-15) and 14.3 (13-15) days,respectively. Eight patients were full donor chimerism and two were in mixed chimerism status. One patient with related donor was transferred to full donor chimerism after infusion of frozen peripheral blood hematopoietic stem cells. Another patient with unrelated donor had decreased peripheral white blood cells,red blood cells and platelets three months after transplantation; STR-PCR indicated graft rejection; second transplantation was performed with the same donor and hematopoiesis of the patient origin was achieved gradually. One case developed grade Ⅱ aGVHD and two developed limited cGVHD.Three patients had pure red cell aplasia and achieved hematopoiesis reconstitution after plasma replacement. All the patients survived with a median period of 33 months (3-92) at the end of follow-up. Conclusion Allo-PBSCT with ATG plus CTX as reduced intensity conditioning regimens is an effective therapy for patients with SAA; it has less complication and is worth popularizing in clinical practice.
【Fund】: 上海市卫生系统百人计划基金资助项目(BR98029)
【CateGory Index】: R556
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【References】
Chinese Journal Full-text Database 1 Hits
1 YANG Ming,ZHANG Jun-feng,CHEN Ying,TAO Xi-kai(Nanjing University of Chinese Medicine,Nanjing 210046,Jiangsu,China);Study on Similarity between Stem Cell and "Jing" Based on Modern Study of Traditional Chinese Medicine[J];Journal of Liaoning University of Traditional Chinese Medicine;2011-02
【Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Jianmin, ZHANG Wei ping,SHENG Zhixiang, et al. PBSCT Team of Shanghai (S999), Shanghai 200433, China;Allogeneic peripheral blood stem cell transplantation in treatmemt of leukemia[J];Shanghai Medical Journal;2003-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIU Feng 1 ,CHEN Yuan-yu 1 ,LI Guan_wu 2, ,et al (1.The Second affiliated hospital,Shantou University Medical College,Shantou,515041China;2.Laboratory of Tumor Molecular Biology,Shantou University Medical College,Shantou515041,China);Activation of the Stat1Protein in the Peripheral Blood White Cells of the Patients with Acute Myeloid Leukemia[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-04
2 The First People's Hospital of Chaohuo City, Chaohu 238000, Anhui DING Gang;Therapeutic Effect of CAG Regimen for Acute Myeloid Leukemia in Elderly Patients[J];Journal of Anhui Health Vocational & Technical College;2010-02
3 The Second People's Hospital in chizhou city,chizhou 247000,Anhui BAO Shi-ping;All-trans Retinoic acid combined arsenic trioxide in the treatment of acute promyelocytic leukemia Clinical analysis of 21 cases[J];Journal of Anhui Health Vocational & Technical College;2010-03
4 The First People's Hospital of Chaohuo City,Chaohu 238000,Anhui DING Gang;Efficacy of Low-dose thalidomide combined with VAD regimen on Multiple myeloma[J];Journal of Anhui Health Vocational & Technical College;2010-06
5 Wu Fan, Xia Ruixiang Department of Hemology, the First Affiliated Hospital of Anhui Medical Unirersity,Hefei 230022;Analysis on the treatment of acute promyelocytic leukemia[J];Anhui Medical Journal;2009-06
6 Liu Zhaoxia,Lu Wen,Qian Hao Department of Nephrology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Huang Kaiquan,Zhang Shufang,Shen Rong[J];Anhui Medical Journal;2010-03
7 Liang Hong,Yao Fusheng,Zhang Lin,et al Anhui Medical University Affilited Anqing Hospital,Anqing 246003,China;The combination of all-trans retinoic acid and arsenic trioxide for the treatment of acute promyelocytic leukemia[J];Anhui Medical Journal;2011-04
8 Zhu Lingyan,Zeng Qingshu Department of Hematology,The first affiliated hospital,Anhui Medical University,Hefei 230022,China;The influence of the anticoagulant in detection of the ITP anti-platelet GPⅡb/Ⅲa and GPIbα antibodies on MAPIA[J];Anhui Medical Journal;2011-06
9 Ge Jian,Zeng Qinshu,Yang Mingzheng,et al Department of Hematology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;The therapeutic effect of CAG regimen and FLAG regimen on patients with refractory or relapsed acute myeloid leukemia[J];Anhui Medical Journal;2012-03
10 Wang Jian,Xu Zhe,Cheng Bangning Department of Hematology,Anhui Provincial Children's Hospital,Hefei 230051,China;Discussion on changes in T lymphocyte subsets,NK and B cells in children with acute ITP[J];Anhui Medical Journal;2012-03
China Proceedings of conference Full-text Database 8 Hits
1 Li Xiao-long~*,Huang Xiu-feng,Xu Fei,Wang Wei-wei,Huang Xiao-fang,Wang Sai-Fang,Liu Huan-le,Wang Jin-guo,Liu Hui.Department of laboratory medicine,The first affiliated Hospital of Wen Zhou Midical college,Wen Zhou 325000,china;The significance of Ret-he in diagnosing iron deficiency anemia[A];[C];2011
2 YU Ling-ling l,TIAN Ke-gang 2,FENG Jing-jing 3,WANG Hui-yan l,ZHENG Mei-qin 4,YU Jian l,LV Jian-xin 2,ZHENG Xiao-qun l.(1 The Second Affiliated Hospital of Wenzhou Medical College,Wenzhou,Zhejiang,325027,China;2 Wenzhou Medical College, Wenzhou,Zhejiang,325035,China;3 The Hospital of Binjiang,Hangzhou,Zhejiang,311100,China;4 Ophtha lmologic Affiliated Hospital of Wenzhou Medical College,Wenzhou,Zhejiang,325027,China);Establishment of a Method for Detection of Gene Mutations by High-resolution Melting Analysis inβ-thalassemia and its Clinical Application.[A];[C];2011
3 He Yuan;A clinical analysis on 17 IRP patients.[A];[C];2008
4 FENG Yonghuai CHEN Qi;Expression patterns of CD40-CD40L costimulatory molecule on acute lymphocytic leukemia(ALL)[A];[C];2008
5 YUAN Zhong LUO Shi-Xi YANG Min ZHU Xi MAO Cheng-Mei(Department of Hematology,Affiliated Hospital of Zunyi Medical College;Zunyi 563003.China);The clinical efficacy of autologous peripheral stem cell transplantation therapy for malignant hematopathy[A];[C];2008
6 Hu Jieying~1,Jiang Dongxia~2,Fan Ruihua~2,Guo jindong~2,Wei Xudong~2, Fu Yuewen~2,Song Yongping~2 (1,Henan Institute of Tumor;2,Henan Tumor Hospital,Zhengzhou,China.);Chromosomal karyotype analysis in 69 patients with myelodysplastic syndrome[A];[C];2009
7 Zhao Hong-Yun~1,Zhong Xue-Yun~2,Chen Yun-Xian~3,Jiang Wen-Qi~1,Guan Zhong-Zhen~1 1..Department of Oncology,Cancer Center,Sun Yat-Sen University,Guangzhou, Guangdong,510080,P.R.China; 2..Medical Hospital,Ji Nan University,Guangzhou,Guangdong,510630,P.R.China; 3 Department of Hematology,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China;;Relationship between Tumor Necrosis Factor Genetic Polymorphisms and clinical course,outcome of Non-Hodgkin's Lymphoma[A];[C];2009
8 ZHU Shi-hong.Yuxi people's Hospital,Yuxi Yunnan 653100,china.;Megakaryocyte of Bone Marow in 352 Cases with Iron Deficiency Anemia[A];[C];2011
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 YAO Zhong xiang, LI Wei, LI Cheng ren, QIN Mao lin, LIU Jian jun, CHEN Xing shu, ZHOU De shan (Department of Histology and Embryology, Third Military Medical University, Chongqing Institute of Neuroscience, Chongqing 400038, China);Study of the neural stem cells differentiated into pancreatic islet-like tissue in vitro[J];Acta Academiae Medicinae Militaris Tertiae;2003-01
2 ZHANG Chun~1 XIA Linghui~1 YOU Yong~1 HE Jing~1 SONG Shanjun~1(~1Institute of Haematology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China);Clinical study of HLA partially mismatched peripheral blood stem cell transplantation for treatment of acute leukemia[J];Journal of Clinical Hematology;2004-05
3 Yu Zijiang1,Ying Dajun2,Cui Xiaoping2,Dong Shiwu2(1Department of Anatomy,Basic Medical College,Guiyang Medical University,Guiyang 550004;2 Department of Anatomy,College of Basic Medicine,Third Military Medical University,Chongqin 400038);LEARNING AND MEMORY AMELIORATION AFTER TRANSPLANTATION OF THE NEURAL STEM CELLS MODIFIED WITH NOGGIN GENE ON AGING MICE[J];Chinese Journal of Neuroanatomy;2007-06
4 An Hongmei,Hubing,Shi Yunfeng,Xu Liwen,Hu Yunhao,Gu Yun(Hualong Hospital Attached to Shanghai University of Chinese Medicine,Shanghai 200032);The Effect of Bu Shen Tian Jing Complex Prescription Serum on the Aging of WI38 Cells[J];Journal of Shaanxi College of Traditional Chinese Medicine;2007-01
5 Zhu Zhi-gang,Li Qing-shan,Wang Han-ping,Wang Shun-qing,Mao Ping Department of Haematology,Guangzhou First People's Hospital,Guangzhou 510180,Guangdong Province,China;Nonmyeloablation allogeneic peripheral blood hematopoietic stem cell transplantation for beta-thalassemia major in one case[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-03
6 Gu Hai-gang1, Long Da-hong2, Li Xiao-bin1, Zhang Gui-ping3, Su Tao4, Li Jia-mei2, Leng Shui-long21Department of Histology and Em- bryology, 2Department of Anatomy, 3Department of Pharmacology, Guangzhou Medical College, Guangzhou 510182, Guangdong Province, China; 4Institute of Neuro- science, Second Affiliated Hospital of Guangzhou Medical College, Guangzhou 510260, Guangdong Province, China;Effect of neural stem cells transplantation on parvalbumin-positive neurons of the basal forebrain and abilities of learning and memory in a rat model of senile dementia[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-12
7 Tang Xiao-qiong, Liu Lin, Chen Jian-bin, Wang Jian-yu, Zhang Hong-bin, Xiao Qing, Liao Ming-yan, Hu Zong-huiDepartment of Hematology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China;Allogeneic hematopoietic stem cell transplantation for treatment of leukemia in 9 patients[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-10
8 Wang Xing-bing,Liu Hui-lan,Geng Liang-quan,Liu Xin,Yang Hui-zhi,Han Yong-sheng,Tang Bao-lin,Zhu Wei-bo,Wang Zu-yi,Sun Zi-min Department of Hematology,Anhui Provincial Hospital,Anhui Medical University,Hefei 230001,Anhui Province,China;HLA-matched sibling donor allogeneic hematopoietic stem cell transplantation for treatment of chronic myeloid leukemia in 40 cases[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-14
9 GAO Chang, WANG Jing zhou, FAN Wen hui, CHEN Man e. Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing 400042, China;Effects of intravenous administration of marrow stromal stem cells on cognitive impairment of vascular dementia rat models[J];Chinese Journal of Geriatrics;2004-11
10 CUI Cheng-de, ZHANG Jie, LI Yun, XU Qi (Institute of Basic Theory of TCM.China Academy of Traditional Chines Medicine,Beijing 100700,China);Effect of Prescriptions for Tonifying Kidney and Benefiting Essence of Life on Topoisomerase Ⅱ Activity of the Different Organs of Senile Rats[J];China Journal of Basic Medicine In Traditional Chinese Medicine;2004-05
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 SHEN Rong,XU Cong-gao,LI Li-zhen,ZHANG Ti,QIN Xue-mei,LI Jie,ZHAO Chuan-li. Qilu Hospital of Shandong University,Jinan250012,China Corresponding author:XU Cong-gao;Study on the T lymphocytes early activation and soluble tumor necrosis factor receptor in patients with aplastic anemia[J];Chinese Journal of Hematology;2004-04
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