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《SHANGHAI MEDICAL JOURNAL》 1998-09
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Study on the apoptosis in PC12 cell induced by dopamine

Zhou Guoqing, Zhou Xiaoda, Li Ningli, et al. Department of Neurology, Renji Hospital,Shanghai Second Medical University, Shanghai 200001  
Objectives:To study the mechanism of dopaminergic neuronal death in substantia nigra of Parkinson's diseaes(PD). Methods:The effect of dopamine(DA) on apoptotic PC12 cell were examined by fluorescence microscopy using the DNA end-labeling methods. Results:DA may induce apoptosis in PC 12 cell,moderate concentrations of DA(0.45mmol/L4) giving maximal number of apoptotic cell (rate of apoptosis:48.7%±6.3%);and the antioxidant N-acetyl-cysteine(NAC) partially prevent DA-induced apoptosis in PC12 cells(P0.01). Conclusion:Apoptosis may be involved in the pathogenesis of PD, and treatment with proper antioxidants amy be useful in PD therapy.
【CateGory Index】: Q28,R742.5
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