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《Shanghai Journal of Medical Laboratory Sciences》 2005-01
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The clinical observation of serum soluble Fas and soluble Fas ligand levels in renal allograft rejection patients

DING Lili, XIE Songye, CAI Yiting. Department of Clinical Laboratory, The First People’s Hospital, Shanghai Jiaotong University, Shanghai 200080, China  
Objective To observe the serum levels and clinical significance of solubel Fas (sFas) and soluble Fas ligand (sFasL) in patients with acute allograft rejection after kidney transplantation. Methods sFas and sFasL concentrations of control group and test group were measured by ELISA. Sera of the test group were determined before and after dialysis. Results sFas and sFasL concentrations in control group were ( 256.8±72.0)ng/L and ( 227.9 ±65.9)ng/L respectively; In patients before and after dialysis, sFas concentration was ( 1 225.7 ±467.6)ng/L and ( 1 225.8 ±464.0)ng/L respectively, sFasL concentration was ( 227.9 ±147.2)ng/L and ( 226.9 ±109.6)ng/L respectively. There was statistically significant difference in sFas concentration between control and test group (P 0.01). There was no significant difference of sFasL between two groups (P 0.05). Conclusions The high sFas level in serum plays an inhibition role in apoptosis, and dialysis can not improve Fas-FasL mediated apoptosis.
【CateGory Index】: R699.2
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