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《Shanghai Journal of Medical Laboratory Sciences》 2005-01
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The clinical observation of serum soluble Fas and soluble Fas ligand levels in renal allograft rejection patients

DING Lili, XIE Songye, CAI Yiting. Department of Clinical Laboratory, The First People’s Hospital, Shanghai Jiaotong University, Shanghai 200080, China  
Objective To observe the serum levels and clinical significance of solubel Fas (sFas) and soluble Fas ligand (sFasL) in patients with acute allograft rejection after kidney transplantation. Methods sFas and sFasL concentrations of control group and test group were measured by ELISA. Sera of the test group were determined before and after dialysis. Results sFas and sFasL concentrations in control group were ( 256.8±72.0)ng/L and ( 227.9 ±65.9)ng/L respectively; In patients before and after dialysis, sFas concentration was ( 1 225.7 ±467.6)ng/L and ( 1 225.8 ±464.0)ng/L respectively, sFasL concentration was ( 227.9 ±147.2)ng/L and ( 226.9 ±109.6)ng/L respectively. There was statistically significant difference in sFas concentration between control and test group (P 0.01). There was no significant difference of sFasL between two groups (P 0.05). Conclusions The high sFas level in serum plays an inhibition role in apoptosis, and dialysis can not improve Fas-FasL mediated apoptosis.
【CateGory Index】: R699.2
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Xia Chengqing, Zhao Hongying, Tang Xiaonai Department of Pathology, Beijing Red Cross Chaoyang Hospital(Beijing,100020);THE INCREASE OF RENAL FAS AND FAS L EXPRESSION IS ASSOCIATED WITH RENAL ALLOGRAFT REJECTION[J];CHINESE JOURNAL OF NEPHROLOGY, DIALYSIS & TRANSPLANTATION;1998-04
2 JIANG Jianping, HOU Fanfan, LIU Zhiqiang, et al Renal Division, Nanfang Hospital, Guangzhou 510515, China;Expression of Fas on monocytes and the level of plasma soluble FasL in patients with chronic renal failure[J];Chinese Journal of Internal Medicine;2001-01
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 JIN Jiansheng,ZHENG Xiangxiong,LIN Qingyou,et al Department of nephrology,Union Hospital,Fujian Medical University,Fuzhou (350001);Effect of Radix Astragali on sFasL and T Cell Subsets in Patients with Uremia[J];Chinese Journal of Integrated Traditional and Western Nephrology;2002-03
2 Xia Chengqing, Xing Changhong, Tang Xiaonai (Department of Pathology, Chaoyang Hospital,Capital University of Medical Sciences,Beijing 100020);Quantitative analysis of the expression of Fas in adenocarcinoma of colon[J];Chinese Journal of Clinical and Experimental Patholog;2002-03
3 ZHANG Ji-hong, SUN Bo, JIANG Jing, et al. (Affiliated Hospital of Beihua University, Jilin 132001, Jilin, P. R. China);The expression and significance of apoptotic genes Fas in large intestine cancer and neighboring tissues[J];China Tropical Medicine;2005-08
4 YU Lixin1, MA JUNjie1, YANG Lijian2, LI YaNgqiu2, LIU Qifa3, XU Bing3 1Dept. of Kidney Transplantation, Nan Fang Hospital, Guangzhou, 510515; 2Dept. of Hematology, Jinan University, Guangzhou, 510632; 3Dept. of Hematology, Nan Fang Hospital, Guangzhou, 510515;Genescan analysis of clonality of TCR Vβ repertoire T cell in patients with maintenance hemodialysis[J];Chinese Journal of Nephrology, Dialysis & Transplantation;2004-01
5 XIA Chengqing, ZHAO Hongying, TANG Xiaonai.Department of Pathology,Chaoyang Hospital, Capital Medical University, Beijing 100020.;The expressions of Fas and Fas-L in human breast invasive ductal carcinomas and their surrounding tissues[J];Chiese Journal of Surgery;1999-11
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