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《Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai》 2009-04
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Effects of Cordyceps Polysaccharides on Fibroblasts Collagens in Photoaging Skin Induced by 8-MOP/UVA

LI Hua1 YE Ting-jie1 LI Bo-qing2 YING Xin-ping21.Basic Medicine School,Shanghai University of Traditional Chinese Medicine2.Teaching Experiment Center,Shanghai University of Traditional Chinese Medicine  
Objective:To study the effects of cordyceps polysaccharides (CP) on fibroblasts collagens in photoaging skin. Methods: The Photoaging skin fibroblast models were induced by 8-MOP/UVA. TEM,hydroxyproline(HYP),MDA quantity and immunocytochemistry were used to test the effects of cordyceps polysaccharides on collagens. Results: Compared with the control group,it was noted that the protein synthesis was not active,the content of HYP was decreased and the content of MDA was increased,the expression of Collagen Ⅰwas decreased,and that of Collagen Ⅲ was increased in the model group. While,these abnormal changes were alleviated in the CP group. Conclusion: Cordyceps polysaccharides can reverse the abnormal changes of fibroblasts collegens in photoaging skin.
【Fund】: 上海市教委青年基金资助项目(05cz02);; 上海市教委重点学科建设项目(J50301)
【CateGory Index】: R285.5
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