Mitochond rian of Experimental Cortical Infarction in Rats

Luo Yong;;Huang Zhongxun;;Xu Chen  

Photochemically initiated focal cortical infarction has been performed. We used the method of morphometry on exploring the effect of acupuncturing "He gu" point on the neuronal mitochondrian of experimental cortical infarction in wistar rats. In order to reflect the ultrastructure of mitochondrian, we used five indexes of morphometry. The mean results were as follows: (1) cortical infaraction group: the volume density (Vv) and the mean diameter(D) of mitochondrian increased markedly (P0.01), the specfic surface(δ) and the numerical density(Nv) of the mitochondrian decreased markedly (P 0.01). It suggested that the neuronal mi- tochondrian of group of cortical infarction swells significantly, and photochemical method can initiate the focal cortical infarc- tion in this experiment. (2) group of cortical infarction + acupuncture: Compared with the cortical infarction group, in this group, both Vv and D of neuronal mitochondrian decreased significantly (P0.01), and δ、 Nv increased significantly (P0.01 and P 0.05). This result showed that acupunc- ture could decreased the edema of cortical neuronal mitochondrian. In general, with the method of morphometry, we make sure that acupuncture could improve cortical in- farction. Because we used acupuncture within the earlier period after photochemical method in this research, it suggested that using acupuncture earlier can improve cere- bral ischemia, these results supported that acupuncture could be used in earlier period after cerebral ischemia.

【Fund】： 卫生部科学研究基金;; 四川省中医管理局资助项目
【CateGory Index】： R245

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