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《Shanghai Journal of Acupuncture and Moxibustion》 2013-07
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Effects of Electroacupuncture at Different Points on Mesenteric Microcirculation and the VIP Content of Different Viscera in COPD Rats

LI Zhi-tong,YANG Wei-ning,XIE Jie-ping,ZHAO Ya-fang,LI Sheng-jie.Beijing University of Traditional Chinese Medicine,Beijing 100029,China  
Objective To observe the effects of electroacupuncture at points Fenglong(ST40) and Chize(LU5) on mesenteric microcirculation and the distribution of vasoactive intestinal peptide(VIP) in different viscera in rats with chronic obstructive pulmonary diseases(COPD),investigate the characteristics of the influences of homo-meridian points and related meridian points on the lung and intestine and explore regularities in the relative specificities of acupuncture points.Methods Thirty-two male Wistar rats were randomly allocated to normal,model,Chize and Fenglong groups,8 rats each.A COPD model was made by intratracheal instillation of LPS with the cooperation of fume smoking in all groups except the normal group.Fenglong and Chize groups were given acupuncture once every other day,for a total of 12 treatments.The experimental period was 18 days. Mesenteric microvascular caliber and blood flow were measured in each group of rats.Pulmonary,intestinal and hypothalamic VIP contents were determined by radioimmunoassay.Results Compared with the normal group,blood flow velocity increased significantly in the model group(P0.05) and decreased significantly in the Fenglong group(P0.01).Compared with the model group,blood flow velocity decreased significantly in the Chize and Fenglong groups(P0.01).There was a statistically significant difference between intestinal or hypothalamic VIP content and pulmonary VIP content in each group of rats(P0.01,P0.05). There was a statistically significant difference in hypothalamic VIP content between the Chize and model groups of rats(P0.05). Conclusions Points Chize(LU5) and Fenglong(ST40) can both prevent a COPD-caused increase in mesenteric microvascular blood flow velocity.Point Chize(LU5) can significantly reduce hypothalamic VIP content,suggesting that point Chize(LU5) preventing a COPD-caused increase in blood flow velocity is related to it reducing hypothalamic VIP content.
【Fund】: 北京中医药大学自主选题项目在读研究生资助项目(2011-JYBZZ-XS099)
【CateGory Index】: R245
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