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《Journal of Shihezi University(Natural Science)》 2018-01
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Analysis of click induced auditory brainstem responses of normal adult CBA mice

Wang Meng;Dong Yumei;Wang Haiyan;Hong Yu;Gui Fei;Song Xiaoming;Sun Xiaopin;Yang Yi;Tan Xiaohua;Chen Rong;Song Yang;Huang Jin;Yang Lei;School of Medicine,Shihezi University;School of Medicine,Hangzhou Normal University;  
To obtain the auditory brainstem response(ABR) wave of normal CBA adult mice, and further to analyze the thresholds, latent period and amplitudes, so as to provide reference frame for further mice auditory research. Applied click ABR test to 50 normal CBA mice. The occurrence rate of wave Ⅰ,Ⅱ,Ⅲ,Ⅳ,Ⅴ under high level(90 d B SPL), moderate level(60 d B SPL) and low level(30 d B SPL), were observed respectively. The wave with the highest occurrence rate to determine the threshold value was analyzed. Meanwhile, its latent period and amplitudes were measured. as the result showed that the occurrence rates of wave Ⅰ,Ⅱ,Ⅲ,Ⅳ and Ⅴ were 100%, 100%, 100%, 100%, 65% at high levels, 100%, 100%, 100%, 100%,59% at moderate levels and 95%, 97%, 65%, 55%, 45% at low levels. Wave II, with an average threshold was 30 d B SPL,had the highest wave lead rate and stability. which was the most suitable to judge the response thresholds, compared to other waves. According to observation, when sound intensities changed from 90 to 30 d B SPL, the latent period would be 2.08-2.35 ms and amplitude range would be 2.15-1.62Μv, respectively. It can be concluded that wave II, induced by click sound, showed the highest wave lead rate and stability. The stimulation intensity of wave II is the reference frame for its response thresholds value.
【Fund】: 杭州市重大科技创新项目(20152013A01)
【CateGory Index】: R764
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