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《Shanghai Journal of Traditional Chinese Medicine》 2001-06
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Experimental Study on the Influence of Curcumae on Extracellular Matrix of Kidney

Longhua Hospital Affiliated to Shanghai University of TCM DU Lan pingHU Zhong yiDENG Yue yiCHEN Yi ping  
To investigate the mechanism of curcumae in the prevention and treatment of chronic nephritis and renal insufficiency,24 SD rats were classified into group A,group B and group C.Rats in group B and C were made to have unilateral ureteral obstruction(uuo).In addition,the rats in group C were treated by pouring curcumae decoction into stomach.6 day later,the rats were sacrificed,and the expressions of CD 8 +T cells,collagen fibers Ⅲ and Ⅳ,fibronectin(FN),laminin(LN),α smooth muscle actin(α SMA)and transformation growth factor β(TGF β)were observed.Results showed that the indexes in group C were improved obviously( P 0.05~0 01),indicating that curcumae could degrade the extracellular matrix,reduce the infiltration of CD 8 +T cells and influence the production of TGF β to improve the renal function.
【CateGory Index】: R285.5
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