Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Shanghai Journal of Traditional Chinese Medicine》 2008-01
Add to Favorite Get Latest Update

Effects and Significance of Quercetin plus TNP-470 on ES and VEGF of Transplanted Tissues in Lung Adenocarcinoma Mice

ZHANG Yi-kang Department of Chinese Medicine,The First Affiliated Hospital of Nanhua University  
Objective To study the effects and significance of quercetin and TNP-470 on ES and VEGF of the transplanted tissues in lung adenocarcinoma mice.Methods LA795 cells were subcutaneously inoculated into the mammary fatty pad of T739 mice to clone lung adenocarcinoma model.Four days after inoculation,40 mice were randomized into four groups(10 mice in each group):control group in which every mouse was peritioneally injected with 0.2 ml 0.9% sodium chloride aqua every day,16 times in all;TNP-470 group in which every mouse was injected with TNP-470 for(30 mg·kg~(-1)·d~(-1))next days,7 times in all;quercetin group in which every mouse was injected with quercetin(5 mg·kg~(-1)·d~(-1))once a day,16 times in all;Alliace group in which:the dose is consisted with those in quercetin group and TNP-470 group.After transplantation and all mice were sacrificed after 24 days,lung metastatic occurrence rat were counted and wet weight after peeling the subcutaneous tumor was measured,fix the specimen of tumor,immunohistochemistry method with image analysis system was applied to detect the ES and VEGF in tumor tissues.Results The lung metastatic and wet weight in every treatment group was significantly lower than those in the control group,the lowest in the Alliace groups,with a significance;the effect of ES in tumor tissue of very treatment group was higher than that of the control groups;the highest in the Alliace group,with a great difference;the expression of VEFG in tumor tissue of very treatment group was lower than that of the control groups;the lowest in the Alliace groups, with a significant difference;the effect of ES has a negative relationship with the effect of VEFG,the lung metastatic and wet weight,the effect of VEFG had a negative relationship with the lung metastatic and wet weight.Conclusion Quercetin and TNP-470 may inhibit expression of VEGF,promote expression of ES,hence inhibits growth and metastasis of tumor.
【CateGory Index】: R734.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 4 Hits
1 WANG Xiao-Hua1, WANG Zheng2, DUAN Bao-Chun2, SONG Jie-Tao2, HE Jian-Bin1, OU Li-Wen1, ZHANG Ping1 1. Department of Respiration Medicine, The First Affiliated Hospital, Nanhua University, Hengyang, Hunan, 421001, P. R. China 2. Medicine Examination Center, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical University, Beijing, 100021, P. R. China;Inhibitory Effect of Fumagillol Combined with Cyclophosphamide on Metastasis of Lung Adenocarcinoma Cell Line LA795 Xenograft in Mice[J];Chinese Journal of Cancer;2005-12
2 HE Jian-bin, ZHANG Ping, OU Li-wen, WANG Xiao-hua Department of Respiration, First Affiliated Hospital of Nanhua University, Hengyang 421001, P.R.China;Expressions of HIF-1α and P-Selectin induced by Suramin combination with Quercetin in lung adenocarcinoma in mice[J];Chinese Journal of Cancer Prevention and Treatment;2006-11
3 ZHAO Lin, HAN Biao , LIU Jian,JIANG Peng and MA Min-jie (Department of Thoracic Surgery, The First Affiliated Hospital of Lanzhou Medical College, Lanzhou,Gansu 730000,China);Expression and significance of vascular endothelial growth factor in human esophageal carcinoma[J];China Journal of Modern Medicine;2004-02
4 WANG Li-zhong, HE Jian-bin, LI Jie-ping, ZHANG Shu-jie, ZHANG Ping (Department of Respiration, the First Affiliated Hospital of Nanhua University, Hengyang, Hunan 421001, P.R.China);Expression of NF-КB and HIF-1a induced by Quercetin combination with DDP in lung adenocarcinoma in mice[J];China Journal of Modern Medicine;2006-09
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 HE Jian-Bin1, YI Gao-Zhong1, YANG Kai1, XIANG Zhi1, XIE Mao-Feng1, ZHANG Ping21. Department of Respiratory Diseases, The First People’s Hospital of Huaihua City, Huaihua, Hunan, 418000, P. R. China 2. Department of Respiratory Diseases, The First Affliliated Hospital, Nanhua University, Hengyang, Hunan, 421001, P. R. China;Inhibitory Effects of Suramin on Growth of Transplanted Lung Adencarcinoma in Mice and Its Mechanisms[J];Chinese Journal of Cancer;2008-04
2 OU Li-wen,LUO Yun-hai.The Department of Respiratory,the affiliated hospital of XiangNan University.Huo Jianbing,Zhang Ping,The teaching and research unit of clinic nurse,The nurse college of NanHua University;The effect of suramin in combination with adriamycin on HIF-1α and VEGF expressions in mice transplanted with lung adenocarcinoma[J];Journal of Chinese Physician;2006-11
3 YAO Miao-miao, LAI Yong-hong, ZHAI Ying-ying (Department of Pediatrics, First Affiliated Hospital , Guangzhou Medical College, Guangzhou 510120, China);Antitumor Effects of Quercetin in P388 Leukemia Mice[J];Academic Journal of Guangzhou Medical College;2008-01
4 HU Hui-qun,CAO Pei-guo,TANG Xue-yuan,et al(Department of Oncology,the Third Xiangya Hospital,Central South University,Changsha,Hunan 410013,China);Influence of TNP-470 in Combination With 5-FU on the Growth of Gastric Cancer and its Mechanism Involved in SCID Mice[J];Journal of Nanhua University(Medical Edition);2007-06
5 LI Yu-mei,CHEN Yong-qiang Department of Orthopedics and Traumatology,Shanghai Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,P.R.China;Hypoxia-inducible factor-1,a novel target for cancer cell apoptosis and angiogenesis[J];Chinese Journal of Cancer Prevention and Treatment;2008-12
6 LU Yue,LIN Song-yi,ZHANG Yan,LIU Jing-bo(Laboratory of Nutrition and Functional Food,College of Quartermaster Technology,Jilin University,Changchun 130062,China);Study on Enzymatic Preparation of Quercetin from Crude Alcohol Extract of Vaccininm uliginosum L.[J];Food Science;2008-12
7 HUANG Qin-jie1,JIANG Ju1,LU Bin-bin2,JIANG Hui1 1Qidong Liver Cancer Institute,Jiangsu 226200,China;2Department of clinic oncology,Second Hospital afilliated Nanjing Medical University,Nanjing 210011,China.;VEGF shRNA eukaryotic expression vector effect to tumor of human hepatocellular carcinoma[J];Journal of Modern Oncology;2008-02
8 XIAO Yi-jun, CHEN Yuan-zhong, CHEN Bing-hua, HUANG Mei-juan, YU Ping-li, LIN Jin-juan (Fujian Institute of Hematology, Union Hospital, Fujian Medical University, Fuzhou Fujian 35000 , China);Nispex inhibits myeloid leukemia cell HL-60 growth in vitro and in mice[J];China Oncology;2007-06
9 ZHU Lan-yan1, CHEN Ping1, JIANG Yun-sheng2(1. Department of Reaspiratory Medicine, 2. Department of Nephrology, the Second Xiangya Hospital, Central South University, ChangSha, Hunan 410011, P.R.China);Expression of HIF-1α and VEGF in non small cell lung cancer and relationship between them and tumor angiogenesis[J];China Journal of Modern Medicine;2005-07
10 LIU Xiao-ling, WANG Wen, JIANG Ying, WANG Cheng (Department of Radiotherapy, the First Hospital of Xi'an Traffic University, Xi'an, Shanxi 710061, P.R.China);Assay squamous cell carcinoma antigen level in patients with esophageal cancer[J];China Journal of Modern Medicine;2005-09
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 XIA Jing lin,YANG Bing hui,YE Sheng long,et al Liver Cancer Institute,Zhongshan Hospital,Shanghai Medical University, Shanghai 200032,P R China;An experimental study of the inhibitory effect of the combination of TNP-470 and MMC on the growth and metastasis of human hepatocellular carcinoma[J];CHINESE JOURNAL OF CANCER;2000-04
2 MA Shuang-wei,WU Kai-nan,ZHONG Xiao-gang,KONG Ling-quan Department of General Surgery,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,P.R.China;Study of the inhibitory effect of quercetin on transplantation tumor of breast carcinoma cell line MCF-7 in nude mice[J];Journal of Qilu Oncology;2004-03
3 WANG Liang,JIN Xiyu,SONG Bo,Department of Urology,Southwestern Hospital,Third Military Medical University,Chongqing 400038,China;Effects of angiogenesis inhibitor TNP-470 on mouse bladder cancer[J];CHINESE JOURNAL OF UROLOGY;2000-08
4 GUO Wenzhong, RAN Yuliang, WANG Guiqi, LIU Jun, YU Long, SUN Lixin, YANG Zhihua. Cancer Institute(Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China;Expression and hypoxic regulation of vascular endothelial growth factor and matrix metalloproteinase-9 in esophageal carcinoma[J];Chinese Journal of Oncology;2002-01
5 Wang Haidong, Wang Mingrong, Jing Tao, Yang Kang, Yang Junmin The Department of Cardiovascular and Thoracic Surgery, Southwest Hospital, the Third Militry Medical University, Chongqing 400038;THE CLINICAL SIGNIFICANCE AND EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR AND IT'S RECEPTOR IN ESOPHAGEAL CARCINOMA[J];CHINA JOURNAL OF MODERN MEDICINE;2000-10
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved