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《Chinese Journal of Neuroanatomy》 2002-03
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THE EXPRESSION OF NEUROTROPHIC FACTORS (NGF?BDNF) AND RECEPTORS, TrkA, TrkB AND TrkC IN THE SPINAL CORD OF THE MONKEY

Wu Xiaoqiong, Li Changqi, Liu Dan, Cai Weijun, Luo Xuegang (Department of Neurobiology, Xiang Ya Medical College, Central South University, Changsha 410078)  
To investigate the expression of neurotrophic factors and their receptors in the spinal cord of adult monkey, immunohistochemistry with antibodies against neurotrophic factors nerve growth factor(NGF), brain derived neurotrophic factor(BDNF) and the neurotrophic factor receptors, trkA?trkB and trkC was used. NGF immunoreactive positive neurons were present in all the laminae of grey matter, glial cells in the grey and white matter were positively stained for NGF. BDNF immunoreactive positive neurons were observed in different neurons of spinal cord, especial in motoneurons, trkA?trkB and trkC immunoreactivity was observed in neurons and glial cells of the grey matter. The data suggest that neurotrophins may play an important role in maintaining the physiological function of neurons in the spinal cord. (Figures a~h on plate 50)
【Fund】: “973”(G19990 5 40 0 9)课题资助项目
【CateGory Index】: Q421
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