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《Chinese Journal of Neuroanatomy》 2003-02
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THE EXPRESSION CHANGES OF NT-3 AND NT-4 IN NEURONS FOLLOWING CRUSHED SPINAL CORD INJURY

Li Ming, Wang Tinghua *, Lu Hua *, Zhu Xingbao *, Feng Zhongtang * (Department of Anatomy, *Institute for Research on Neuroscience, Kunming Medical School, Kunming 650031)  
To explore the expression changes of NT 3 and NT 4 in the spinal cord neurons in early stage following crushed spinal cord injury (cSCI), immunohistochemical ABC staining and the positive neurons counting methods were used on the 20 μm transections of rat. The resuet showed that NT 3 positive products were mainly distributed in nucleus and NT 4 positive products were distributed in nucleus and cytoplasm. The 7d and 21d groups were significantly higher than the normal and 24 h groups on the NT 3 positive neurons counting in the ventral horn following cSCI( P0.01), only 21 d group was significantly higher than the normal group in the dorsal horn (P0.01). But 24 h, 7 d and 21 d groups were significantly higher than normal group on the NT 4 positive neurons counting in the ventral horn following cSCI (P0.01), and the 7 d and 21 d groups were significantly higher than the normal and 24 h groups in the dorsal horn(P0.01). There was a trend of increase with time following cSCI (P0.01). The results indicate that the number of NT 3 and NT 4 positive neurons is increased in the spinal cord ventral and dorsal horns following cSCI, and the increased endogenous NT 3 and NT 4 may play an role in early repairment of nerve injury following cSCI.
【Fund】: 云南省自然科学基金 ( 2 0 0 0 C0 0 5 7M);; 云南省教委基金 ( 0 0 12 0 12 )资助项目
【CateGory Index】: R361
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