Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Neuroanatomy》 2005-03
Add to Favorite Get Latest Update

HIGH CONCENTRATION OF IRON IN CEREBROSPINAL FLUID OF RATS INDUCES ALZHEIMER-LIKE BEHAVIORAL AND PATHOLOGICAL CHANGES

Li Lin, Wu Jianliang, Jin Zheng, Dou Yan (Geratology Institute, Shanxi Medical University, Taiyuan 030001)  
In order to estimate the relationship between iron and the Alzheimer's disease, the behavioral and pathological changes were observed by Morris water maze and immunohistochemical staining respectively after injecting FeCl_3 into brain ventricle of rats. The apoptosis was tested by flow cytometry and the electron microscopy was used to observe ultrastructural changes. There were significant differences in escape latency of time and distance between normal animals and iron treated rats. Percentage and fluorescence intension (FI) of Annexin-V FITC loaded cells undergoing apoptosis were higher in iron treated rats compared with normal animals. Fawn-coloured products of β amyloid protein were interspersedly distributed in extensive areas of cerebral cortex and hippocampus. Under electron microscope, vacuolate degeneration of neuronal processes with mitochondria degeneration and accumulation of microtubule near vacuolar nucleus were observed in iron treated rats. These results suggest that a local higher concentration of iron in brain may induce Alzheimer-like impairment of intelligence and pathological changes.
【Fund】: 归国人员基金(项目编号9957)资助项目
【CateGory Index】: R749.161
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 GONG Guo-qi,MENG Hui,FENG Hua (Department of Neurosurgery,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China);Role of iron ion in development of hydrocephalus in rats[J];Acta Academiae Medicinae Militaris Tertiae;2008-23
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 GONG Guo-qi,MENG Hui,XIA Yong-zhi,FENG Hua(Department of Neurosurgery,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China);Experimental chronic hydrocephalus after intraventricular hemorrhage in rats:establishment of animal model and pathological observation[J];Acta Academiae Medicinae Militaris Tertiae;2008-10
2 MENG Hui,ZHANG Lijun,LU Jiayou,et al Department of Neurosurgery,the PLA Army Minimally Invasive Treatment of Nervous System Diseases Specialist Centers,Southwest Hospital,Third Military Medicine University,Chongqing 400038,China;Levels and their significance of PⅠCP,PⅢNP,HA and laminin in cerebrospinal fluid in posthaemorrhagic chronic hydrocephalus[J];Chinese Journal of Minimally Invasive Neurosurgery;2007-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved