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《CHINESE JOURNAL OF NEUROANATOMY》 1995-04
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PROTECTIVE EFFECT OF BERBERINE ON RAT HIPPOCAMPUS AGAINST CEREBRAL ISCHEMIA

Wei Youzhen; Yao Zhibin;Yuan Qunfang; Chen Yici(Division of Brain Research, Department of Anatomy,Sun Yat-SenUniversity of Medical Sciences, Guangzhou)  
Previously our department's studies demonstrated that berberine effectively protects neurons in hippocampal CA_1 fromdel ayed neuronal death (DND) after 20 min. cerebral ischemia followed by 7 days reperfusion in rat. Four vessele occlusion(4VO) model as described previously by pulsinelli-Brierley was used in this experiment. Morris water maze tests includingplace navigation test and spatial probe test were used for control and ischemic animals behavioural study after short or longterm reperfusion. The results demonstrated that: After cerebral iscvhemia and long-term reperfusion, CA_1 pyramidal neurons were lost almost completely,also,the cell loss in CA2, CA3 of hippocampus was severe. In berberine administratiomgroup,after long-term reperfusion, the alignment of CA1 pyramidal Cells of post-ischemia hippocampus was normal, with cell density 168/mm, the cell density of CA2, CA3, CA4 was normal. The difference between berberine administration and ischemia control groups was significant. After short or long term reperfusion the ischemic animals needed more escape time(latency)than the sham-opersted animals(p 0.01) respectvely in place navigation test. But in spatial probe test, only long-term reperfusion group rats did not swim longer distance (29. 9% ) in platform quadrant than in the others in spatial probetest. In berberine administration groups, after either short or long-term reperfusion, the latencies were not different fromsham-operated animals respectively in place navigation test. In spatial probe test, both two berberine groups animals swama longer distance in platform quadrant(38. 2%, 35. 6%) than in other three quadrants. Berberine effectively protects CA4neurons in hippocampus from DND or progressed death after ischemia and long-term reperfusion, Furthermore, the berberine protected post-ischemia hippocampus has normal spatial learning and memory function.(Figure 5 on plate 52)
【CateGory Index】: R329.4
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