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《Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology》 2017-10
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Fu-Fang Ku-Shen Injection in Combination with Modern Medications in Treating Lymphoma:A Real-world Study Based on Association Rules And Apriori Algorithm

Zhang Yinghui;Xie Yanming;Zhang Yin;Chen Cen;Zhuang Yan;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences;Guang'anmen Hospital,China Academy of Chinese Medical Sciences;School of Statistics,Renmin University of China;Navy General Hospital of PLA;  
This study was aimed to investigate the application rules of Fu-Fang Ku-Shen(FFKS) injection in combination with modern medicines for the treatment of lymphoma in the real world,in order to provide references for rational clinical application of effective medication.Patients diagnosed as lymphoma and treated with FFKS injection from 22 triple-A hospitals in China were enrolled as research objects.Patients' treatment data were extracted from the hospital information system,which was established by the Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,in order to analyze the frequency distribution characteristics of modern medications combined in the treatment.Association rules and Apriori algorithm were used in the analysis of association characteristics of medication combination.The results showed that 3 674 cases fit the inclusion criteria were searched from the data warehouse.In the clinical practice,FFKS injection was frequently combined with modern medications,such as antibiotics,glucocorticoids,5-HT receptor antagonists,immunomodulatory drugs,proton pump inhibitor,chemotherapeutic drugs,and hepatic protector.Its associated modern medication combination showed special rules,which was in consistency with the related diagnosis and treatment of lymphoma guideline.It was concluded that FFKS injection combined with modern medicine in the treatment of lymphoma in the real world was basically in consistency with related guidelines.It was focused on reducing the side effects of chemotherapy,prolonging survival time,and improving quality of life.It provided references for rational clinical drug application of lymphoma.
【Fund】: 国家“重大新药创制”科技重大专项(2015ZX09501004-001-002):基于监测数据的风险信号评估研究 负责人:谢雁鸣、王连心;国家“重大新药创制”科技重大专项(2015ZX09501004-001-009):中药上市后安全性风险信号临床评估及机理研究 负责人:谢雁鸣、王志飞;; 北京市中医药科技发展专项(JJ2014-53):中西药联合应用评价及机制的方法研究 负责人:王连心;; 中国中医科学院自主选题项目(PY1303):中药上市后临床再评价关键技术创新团队 负责人:谢雁鸣
【CateGory Index】: R733.1;TP311.13
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