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《Chinese Journal of Neurosurgical Disease Research》 2008-01
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Establishment and evaluation of cryogenic brain injury model of rats

CHEN Shiwen1,ZHOU Xiaoping 2,HU Xiaowu2 Department of Neurosurgery,Sixth Affiliated Hospital,Shanghai Jiaotong University,Shanghai 200233;Department of Neurosurgery,Changhai Hospital,Second Military Medical University,Shanghai 200433,China  
Objective To establish and evaluate of cryogenic brain injury rat model.Methods Rat dural external was froze by liquid nitrogen.The changes of intracranial pressure was monitored,the behavior function such as walking,balance function at various period after traumatic brain injury was measured and the pathologic study of nerve tissue was detected.Results Intracranial pressure of cryogenic brain injury group was elevated significantly after cryogenic injury,the maximum value of(14.56±2.31)mmHg appeared 4 h after injury.The walking and balance function was evidently hindered.The nerve pathologic study showed that the edema was found around the nerve cells after cryogenic brain injury.Simultaneously neurons degeneration and necrosis presented in brain cortex congelation injury foci.The nerve cells and glial cells were like vacuoles.ConclusionThe cryogenic brain injury rat model is a stable and reliable brain injury animal model.
【CateGory Index】: R651;R-332
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