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《Chinese Journal of Neurosurgical Disease Research》 2008-05
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The expressions of laminin and laminin receptor 1 in rat brains after experimental intraventricular hemorrhage

MENG Hui,ZHANG Lijun,WANG Junwei,DENG Congying,FENG HuaDepartment of Neurosurgery,Southwest Hospital,Third Military Medical University,Chongqing 400038,China  
Objective To observe the expression of laminin and laminin receptor 1 in rat brains and to study its correlation with the posthaemorrhagic chronic hydrocephalus.Methods Intraventricular infusion of 0.1 ml citrated autologous blood was performed to establish the experimental models of posthaemorrhagic chronic hydrocephalus.The expression changes of laminin(LN) and laminin receptor 1(LNR-1) in rat brains after intraventricular hemorrhage were detected by immunohistochemical techniques.Results Thirty days after intraventricular hemorrhage,4 rats(80%) presented chronic hydrocephalus in the experimental group.After intraventricular hemorrhage,the increase of LN expression in experimental rat brains were found in slit cistern,pia mater,arachnoid,dura and vascular wall.On the 14 th day,the expression of LN reached the peak and demonstrated evident increase compared with the control group(P0.01).The increase of LNR-1 expression in the experimental rat brains was found in cuboidal epithelium of choroids plexus,epithelium of pia mater,arachnoid,dura and vascular endothelial cell.On the 14 th day,the expression of LNR-1 reached the peak and had evident increase compared with the control group(P0.01).Conclusion The increase of LN and LNR-1 expression after intraventricular hemorrhage in rat brains might be involved in the development of arachnoidal fibrosis and posthaemorrhagic chronic hydrocephalus.
【Fund】: 国家“十一五”科技支撑计划资助项目(2006BAI01a12)
【CateGory Index】: R743.35
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