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《Chinese Journal of Neurosurgical Disease Research》 2009-02
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Establishment of rat brain injury model induced by laser

ZHOU Jie1,XIAO Xian1,ZHANG Xiang1,YANG Jiqing2,CHENG Guang1,WANG Jiang1,ZHANG Wei11Department of Neurosurgery,Xijing Institute of Clinical Neuroscience; 2Department of Physics,Fourth Military Medical University,Xi'an 710033,China  
Objective To establish a brain injury model with stability and reliability induced by laser in rats.Methods A total of 100 adult SD rats were randomly divided into sham-operated group without laser irradiation (n=25) and brain injury group induced by 14 J,28 J and 56 J laser respectively (n=75). The brain injury group was subdivided into 6 h,24 h,48 h,72 h and 7 d group with 5 in each. Pathomorphological changes were detected by light microscopy and electron microscopy. Brain edema index,neurological scores and blood pressure were also detected in rats.Results In the brain injury groups induced by 14 J,28 J and 56 J laser,different changes in brain edema index,neurological scores,blood pressure and pathomorphological changes after irradiation were observed,but no difference was observed in sham-operated control group after irradiation.Conclusion The rat brain injury model with stability and reliability induced by laser can be established by 28 J laser with 10.64 μm in wavelength and the optimal working current and the distance are 0.2 mA and 0.5 cm respectively.
【Fund】: 全军医学科学技术研究“十一五”计划指令性课题基金资助项目(06MA235)
【CateGory Index】: R651.15;R-332
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