Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Neurosurgical Disease Research》 2009-02
Add to Favorite Get Latest Update

Establishment of rat brain injury model induced by laser

ZHOU Jie1,XIAO Xian1,ZHANG Xiang1,YANG Jiqing2,CHENG Guang1,WANG Jiang1,ZHANG Wei11Department of Neurosurgery,Xijing Institute of Clinical Neuroscience; 2Department of Physics,Fourth Military Medical University,Xi'an 710033,China  
Objective To establish a brain injury model with stability and reliability induced by laser in rats.Methods A total of 100 adult SD rats were randomly divided into sham-operated group without laser irradiation (n=25) and brain injury group induced by 14 J,28 J and 56 J laser respectively (n=75). The brain injury group was subdivided into 6 h,24 h,48 h,72 h and 7 d group with 5 in each. Pathomorphological changes were detected by light microscopy and electron microscopy. Brain edema index,neurological scores and blood pressure were also detected in rats.Results In the brain injury groups induced by 14 J,28 J and 56 J laser,different changes in brain edema index,neurological scores,blood pressure and pathomorphological changes after irradiation were observed,but no difference was observed in sham-operated control group after irradiation.Conclusion The rat brain injury model with stability and reliability induced by laser can be established by 28 J laser with 10.64 μm in wavelength and the optimal working current and the distance are 0.2 mA and 0.5 cm respectively.
【Fund】: 全军医学科学技术研究“十一五”计划指令性课题基金资助项目(06MA235)
【CateGory Index】: R651.15;R-332
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 4 Hits
1 HUANG Yong LIU Jie (Institute of Combat Systems, Naval Academy of Armament, Beijing 100073, China);Analysis on Kill Mechanism and Characteristics of High Energy Laser Weapon[J];Optics & Optoelectronic Technology;2004-05
2 CHEN Shiwen1,ZHOU Xiaoping 2,HU Xiaowu2 Department of Neurosurgery,Sixth Affiliated Hospital,Shanghai Jiaotong University,Shanghai 200233;Department of Neurosurgery,Changhai Hospital,Second Military Medical University,Shanghai 200433,China;Establishment and evaluation of cryogenic brain injury model of rats[J];Chinese Journal of Neurosurgical Disease Research;2008-01
3 ZHOU Jie,ZHANG Xiang,JIANG Xiao-fan,et al.(Department of Neurosurgery,Xijing Hospital,Fourth(Military) Medical University,710032,China);Protective effects of resveratrol on brain edema and ultramicrostructure of rats with brain trauma[J];Medical Journal of National Defending Forces in Northwest China;2006-02
4 WANG Tong,WANG Hongxing,LI Susu,LU Xiao, WANG Peipei, HOU Hong, SONG Fan.Department of Rehabilitation Medicine, The First Affi liated Hospital of Nanjing Medical University,Nanjing 210029,China;Experimental study of the effect of He-Ne laser irradiation on injured brain injuries in rats[J];Chinese Journal of Physical Medicine and Retabulitation;2002-04
Chinese Journal Full-text Database 10 Hits
1 LI Dong-rong,WANG Fu-chi,MA Zhuang,WANG Quan-sheng,LIU Yan-bo(School of Material Science and Engineering,Beijing Institute of Technology,Beijing 100081,China);Damage Mechanism of Al_2O_3 Ceramic Coatings Irradiated by CO_2 CW Laser[J];北京理工大学学报(英文版);2008-02
2 LAI Xi-nan(Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Some problems about management of blast related craniocerebral injuries[J];Journal of Traumatic Surgery;2010-06
3 WU Yanmei1,2, LI Junchang1(1.Kunming University of Science and Technology,Kunming 650093,China;2.Institute of Command and Technology of Equipment of PLA,Beijing 101416,China);On Heat Destruction Simulation of High-Energy Laser Weapon[J];Electronics Optics & Control;2009-02
4 HAN Jun,ZHANG Duolin,BAI Dongying,YANG Guozhe(Missile Institute,Air Force Engineering University,Sanyuan 713800,China);New Concept Weapon's Requirements to Spatial Information[J];Electronics Optics & Control;2009-02
5 XIA Xin-ren,YIN Cheng-you(Hefei Electronic Engineering Institute,Hefei 230037);Study on propagation properties of laser guiding EMP in a finite magnetic field[J];Nuclear Fusion and Plasma Physics;2009-01
6 XIA Xin-ren, YIN Cheng-you (State Key Laboratory of Pulsed Power Laser Technology, Hefei Electronic Engineering Institute, Hefei 230037);EM scattering analysis of laser plasma channel antenna in a finite magnetic field[J];Nuclear Fusion and Plasma Physics;2009-02
7 XU Guo-liang (Jiangsu Automation Research Institute of CSIC,Lianyungang 222006,China);The Precision Analysis of Shipborne High-energy Laser Weapon Systems[J];Fire Control and Command Control;2009-04
8 LI Yong,WANG Min-le,ZHANG Jun(The Second Artillery Engineering College,Xi′an 710025,China);Damaging evaluation of high-energy laser weapon to ballistic missile[J];Infrared and Laser Engineering;2006-05
9 ZOU Jie, WANG Jing-tao (Luoyang Institute of Electro-optic Equipment, Key Laboratory of National Defence Sciense and Technology on Fire Control Technology , Luoyang 471009, China);General technologies of fire control to airborne directed energy weapon[J];Infrared and Laser Engineering;2008-S3
10 WANG Jing-tao, ZOU Jie (Luoyang Institute of Electro-optical Equipment, Key Laboratory of National Defense Science and Technology on Fire Control Technology, Luoyang 471009, China);Study on concept of missile defense using airborne directed energy weapon[J];Infrared and Laser Engineering;2008-S3
Chinese Journal Full-text Database 10 Hits
1 CHEN Shi-wen,ZHOU Xiao-ping,TIAN Heng-li(Department of Neurosurgery,Sixth Affiliated Hospital,Shanghai Jiaotong University,Shanghai 200233,China);Establishment of cryogenic brain injury model in rats[J];Journal of Traumatic Surgery;2007-03
2 ;Therapeutic effect of HSH on intracranial pressure and brain water content after cryogenic brain injury[J];Journal of Traumatic Surgery;2009-04
3 HE Xiao Sheng, ZHANG Xiang, YI Sheng Yu, FEI Zhou, ZHANG Jian Ning, YANG Li Sun Institute of Neurosurgery of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Ultrastructural characteristics of cerebral microvessels due to instant lateral head rotation in rats[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-09
4 ( WU Xu, WANG Bao-jie, ZHANG Guo-hua, et al. Department of Forensic Pathology, Faculty of Forensic Medicine, China Medical University, Shen yang 110001,China);Animal model of graded impact brain injury in rats[J];Chinese Journal of Forensic Medicine;2005-01
5 Zhang Bensi, Wang Fan, Deng Li, Yang Huijun, Li Ruixiang (Department of Anatomy, School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, China);〔;ISOLATION AND PURIFICATION AND PRIMARY IDENTIFICATION OF RAT BONE MARROW-DERIVED MESENCHYMAL STEM CELLS[J];Chinese Journal of Histochemistry and Cytochemistry;2003-02
6 Zhang Yongliang, Wang Bingkang, Liao Zhigang, Xin Junping, Wu Jiawen, Wu Meiyu.Department of Forensic Pathology, WCUMS, Chengdu 610041;The Establishment of a Modified Lateral Fluid Percussion Model of Brain Injury in Rat and the Pertinent Pathologic Changes[J];JOURNAL OF WEST CHINA UNIVERSITY OF MEDICAL SCIENCES;1999-04
7 MAO Jun-Qing①,QIU Yan②,LI Tie-Jun②,RUI Yao-Cheng②,ZHANG Wei-Dong③(①Department of Pharmacy,Hospital 85 of PLA,Shanghai 200053 China)(②Department of Pharmacology,③Chemistry of Natural Medicine College of Pharmacy,Second Military Medical University,Shanghai 200433 China);Effects of Breviscapine on Learning and Memory Dysfunction of Rats Induced by Traumatic Brain Injury[J];Pharmaceutical Journal of Chinese People's Liberation Army;2007-03
8 Wang Yong~* Lu Changqing Wang Fan~△(Department of Anatomy,School of Preclinical and Forensic Medicine,Sichuan University,Chengdu 610041,China);Differentiation of rat bone marrow stromal stem cells into neuron-like cells induced by salvia mitiorrhiza[J];Chinese Journal of Anatomy;2007-02
9 Wang Xinsheng~1 Cui Huixian~1 Ma Haidong~1 Sun Li~2 Bo Aihua~2 1.Department of Anatomy of Hebei Medical University,Shijiazhuang 050017,China 2.Experimental center of Hebei North College,Zhangjiakou 075029,China;Differentiation of rat bone marrow mesenchymal stem cells induced by astragalus mongholicus[J];Chinese Journal of Anatomy;2007-05
10 ZHAO Nan 1) , FENG Zhong-tang 1) , WANG Ting-hua 1) , YANG Zhi-min 2) , DING Peng 1) , SHENG Xiao-lei 3) ( 1)Institute of Neuroscience, Kunming Medical College, Kunming 650031; 2)Dept. of Neurosurgery, The 1st Affiliated Hospital of Kunming Medical College, Kunming 650032; 3)Dept. of Neurology, Yunnan Red Cross Hospital, Kunming 650031,China);Differentiation of Bone Marrow Stromal Cells into Neuron-like Cells with Salvia Miltiorrhiza Injection[J];Academic Journal of Kunming Medical College;2004-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Huang Dongjian;et al (Depantment of Neuiliungeiy Guangzhou Second Hospital);A Study on the Immunization of Head Injury After Intravascular Laser Irradiation of Blood[J];ACADEMIC JOURNAL OF GUANGZHOU MEDICAL COLLEGE;1997-04
2 Chen Jiandong (Department of Surgery, Lanzhuang Hospital, Lanhai, Guangdong 528219);Endovascular Laser irradiation Therapy on Patients with Early Acute Craniocerebral Injury[J];ACADEMIC JOURNAL OF GUANGZHOU MEDICAL COLLEGE;1999-01
3 Dong Weiren XiaoYing qing Cheng Jieluan (First Military Medical University GZ,China);Combined treatment of cerebrovascular diseases by endovascular laser irradiation of blood[J];LASER JOURNAL;1997-01
4  Wang Qiang,Wu Cuijiao,Jin Liying,et al. Department of Neurology, Qingdao Medical College,Qingdao 266003;The morphological study of microcirculation disturtances in rabbits treated with laser-irradiated blood[J];JOURNAL OF CLINICAL NEUROLOGY;1998-04
5 JIANG Xiaofan1 , ZHANG Xiang1 , XUE Jinghui2 , ZHANG Zhiwen1 , LI Bing1 , NAMURA Shobu3 , YANAMOTO Hiroji3 , NAGATA Izumi31Department of Newosurgery, Xijing Hospital, Fourth Military Medical University, Xian 710032;2 304th Hospital of PLA, Beijing 100037, China;3 Department of Neurovascular Surgery, National Cardiovascular Center, Osaka 5658565, Japan;Protective effect of matrix metalloproteinase inhibitor, KB-R7785 on permanent focal cerebral ischemia in mice[J];Chinese Journal of Neurdsurgical Disease Research;2002-04
6 LIN Jun, ZHOU Xiaoping, YUE Zhijian, HU Xiaowu Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;Experimental study of hypertonic sodium chloride hydroxyethyl starch-40 injection (HSH) on cryogenic brain edema in rats[J];Chinese Journal of Neurosurgical Disease Research;2006-06
7 Peng Ya bin,Zhang Xiang, Jiang Xiao fan,Gao Da kuan Peng Ya bin,Zhang Xiang,Jiang Xiao fan,Gao Da kuan,Department of Neurosurge ry,Xijing Hospital,Fourth Military Medical University of Chinese PLA, Xi'an 7100 32,Shaanxi Province, China;Protective effect of resveratrol on focal cerebral ischemia in mice and its mech anism[J];Chinese Journal of Clinical Rehabilitation;2005-01
8 Huang Dan, Du Kun, Ye Zhongchen (State Food & Drug Administration Medical Device Supervision Testing Center of Hangzhou,Hangzhou 310009);Radiation safety and classification of laser products[J];Applied Laser;2006-04
9 Feng Jiachun;et al;The levels of LPO, SOD and GSH-Px in several brain regions after reperfusion following ischemia[J];JOURNAL OF APOPLEXY AND NERVOUS DISEASES;1994-03
10 Liu ShanlinDepartment of Biochemistry, Shanghai Medical University, Shanghai(200032)Shi Dongyun, Wang Ruyao, Cheng BaihuaShanghai Second Medical University, Shanghai;Effect of Diode Laser Acupuncture on Neurotransmitter Monoaminesin Brain and Malondialdehyde in Plasma of Rats[J];CHINESE JOURNAL OF LASER MEDICINE & SURGERY;1998-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved