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《World Journal of Integrated Traditional and Western Medicine》 2007-12
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Effect of Compound Jiao Gu Lan Medicines on Memory and Brain Monoamine Oxidase Activity of Mice

Deng Jiagang,Du Zhengcai,Hao ErweiGuangxi Traditional Chinese Medical University,Nanning Guangxi 530001  
Objective:To study the proportions of ingredients in Jiao Gu Lan(绞股蓝Gynostemma Pentaphyllum)prescriptions in order to explore the mechanism of compound Jiao Gu Lan medicines.Methods:Experiment(1):The decoction of Prescription A(Jiaogulan+XX,1∶1),Prescription B(Jiaogulan+XX,2∶1),Prescription C(Jiaogulan+XX,3∶1),Prescription D(Jiaogulan+XX+Shi Chang Pu(石菖蒲 Rhizoma Acori Graminei),2∶1∶1),and Prescription E(Jiaogulan+XX,2∶1)+ Bing Pian(冰片Borneolum Syntheticum)was given to five groups of mice respectively through gavage for 5 days.The models were made with haloperidol.The step-down test was done to observe the effect of different prescriptions on memory of mice.Experiment(2):The high and low doses of Shi Chang Pu volatile oil and compound Jiao Gu Lan medicines were given to aging mice respectively for 10 days.The brain protein content and monoamine oxidase(MAO-B)activity were detected.Results:Experiment(1):In the step-down test,compared with the model group,the difference in Prescription B and D groups was significant(P0.05)Experiment(2):Compared with the blank group,the difference of effect of high and low doses of compound Jiao Gu Lan medicines on brain protein contents and MAO-B activity of aging mice was significant(P0.01).Conclusion:(1)The effect of proportion of ingredients in Prescription D was the best and Prescription B was the second.(2)The compound Jiao Gu Lan decoction (Jiao Gu Lan +XX,2∶1)can significantly increase the brain protein content and reduce the MAO-B activity of aging mice.
【Fund】: 第18次中泰科技合作联委会资助项目(No:18-505J);; 广西科技厅基金资助项目(No:0630004-7B34)
【CateGory Index】: R285
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