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《World Journal of Integrated Traditional and Western Medicine》 2010-11
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Anti-Tumor Effect of Lichong Shengsui Decoction on Ovarian Tumor Tissue and the Impact on VEGF Expression in Fischer344 Rats

QIU Li-nan,HAN Feng-juan,WU Xiao-ke,HOU Li-hui (No.1 Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin Heilongjiang 150040)  
Objective To observe the impacts of lichong shengsui decoction on vascular endothelial growth factor(VEGF)of ovarian tumor tissue in rats.Methods Adopt the local thread embedding method with DMBA in ovary to induce ovarian tumor model in rat.Detect anti-tumor rate of lichong shengsui decoction for ovarian tumor.Detect the expression of VEGF in tumor tissue with IHC SABC assay.Results Licong shengsui decoction inhibited ovarian tumor tissue and its anti-tumor rate was different significantly in statistics as compared with guizhi fuling pill(P0.01).Additionally,it reduced apparently the expression level of VEGF gene protein in ovarian tumor cell,indicating significant difference in statistics as compared with model group and guizhi fuling pill(P0.05 or P0.01).Conclusion Chinese herbal compound,lichong shengsui decoction adjusts the excessive expression of VEGF gene protein in ovarian cancer tissue.
【Fund】: 哈尔滨市科学技术局攻关资助项目(No.2005AA9CS116-21)
【CateGory Index】: R285.5
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