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《World Journal of Integrated Traditional and Western Medicine》 2011-08
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Effects of Zedoary Turmeric Oil Injection on SKOV3 Cell Proliferation and Pathological Morphological Changes in Ovarian Cancer

LONG Kang-jian,HAN Feng-juan,WU Xiao-ke,WANG Xi-yue(No.1 Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin Heilongjiang 150040)  
Objective To study the effects of zedoary turmeric oil injection on the proliferation and morphological changes in SKOV3 cell cultured in vitro for human ovarian cancer.Methods MTT method was used to observe the effects of zedoary turmeric oil injection on the proliferation of human ovarian cancer SKOV3 cell.Optical microscopy and transmission electron microscopy were adopted to observe the morphological changes in the cell.Results In the concentration of 120 to 960 μg·mL-1 and the time scope of 24 h,48 h and 72 h,zedoary turmeric oil injection inhibited the proliferation of SKOV3 cell cultured in vitro.Its intensity was enhanced with the up-regulation of the time and the concentration of drug.The time-dose dependence presented.Compared with control group,the difference was significant statistically(P0.05或P0.01).By optical microscopy and transmission electron microscopy,it was observed that the cell in zedoary turmeric oil injection group changed obviously in morphology,resulting in cell necrosis.Conclusion Zedoary turmeric oil injection can remarkably inhibit the growth of SKOV3 cell in vitro and induce the apoptosis.The cell morphology changes obviously,indicating time dependence.
【Fund】: 教育部春晖计划(No.Z2007-1-15001);; 黑龙江省自然科学基金面上项目(No.D200816);; 黑龙江中医药大学杰出人才基金项目(No.200703)
【CateGory Index】: R285.5
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