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《中国神经再生研究(英文版)》 2013-03
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Correlation between the cumulative analgesic effect of electroacupuncture intervention and synaptic plasticity of hypothalamic paraventricular nucleus neurons in rats with sciatica

Qiuling Xu1, Tao Liu1, Shuping Chen2, Yonghui Gao2, Junying Wang2, Lina Qiao2, Junling Liu2 1 Hainan Medical University, Haikou 571101, Hainan Province, China 2 Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China  
In the present study, a rat model of chronic neuropathic pain was established by ligation of the sciatic nerve and a model of learning and memory impairment was established by ovariectomy to investigate the analgesic effect of repeated electroacupuncture stimulation at bilateral Zusanli (ST36) and Yanglingquan (GB34). In addition, associated synaptic changes in neurons in the paraventricular nucleus of the hypothalamus were examined. Results indicate that the thermal pain threshold (paw withdrawal latency) was significantly increased in rats subjected to 2-week electroacupuncture intervention compared with 2-day electroacupuncture, but the analgesic effect was weakened remarkably in ovariectomized rats with chronic constrictive injury. 2-week electroacupuncture intervention substantially reversed the chronic constrictive injury-induced increase in the synaptic cleft width and thinning of the postsynaptic density. These findings indicate that repeated electroacupuncture at bilateral Zusanli and Yanglingquan has a cumulative analgesic effect and can effectively relieve chronic neuropathic pain by remodeling the synaptic structure of the hypothalamic paraventricular nucleus.
【Fund】: supported by the National Natural Science Foundation of China No.30472241 90709031 and 30973796;; the National Basic Research Program of China for Traditional Chinese Medicine Theory(“973” Program) No.2007CB512505;; the Natural Foundation of Hainan Province(No.310054);; a grant from the Health Department of Hainan Province(QiongWei 2010-45)
【CateGory Index】: R245
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