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《中国神经再生研究(英文版)》 2014-02
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Acupuncture/electroacupuncture enhances antidepressant effect of Seroxat:the Symptom Checklist-90 scores

Junqi Chen;Weirong Lin;Shengxu Wang;Chongqi Wang;Ganlong Li;Shanshan Qu;Yong Huang;Zhangjin Zhang;Wei Xiao;The Third Affiliated Hospital of Southern Medical University;The Shenzhen TCM Hospital;School of Traditional Chinese Medicine, Southern Medical University;School of Chinese Medicine, The University of Hong Kong, Hong Kong Special Administrative Region;  
One hundred and five patients with primary unipolar depression were randomly divided into three groups: drug group(Seroxat administration), acupuncture group(Seroxat plus acupuncture), and electroacupuncture group(Seroxat plus acupuncture plus electroacupuncture). Patients' symptoms were evaluated using a psychometric questionnaire, the Symptom Checklist-90, before intervention and after 2, 4, 6 and 10 weeks of treatment. The individual factor scores and the total score from the Symptom Checklist-90 reduced in all three groups as treatment progressed. In the acupuncture and electroacupuncture groups, the total score and the factor scores for obsessive-compulsive symptoms, depression, and anxiety were significantly lower than those in the drug group. There was no significant difference in the factor scores or total scores between the acupuncture and electroacupuncture groups. Some factor scores in the electroacupuncture group, such as somatization, depression, hostility, and phobic anxiety, were increased at 10 weeks compared with the respective score immediately after the course of electroacupuncture at 6 weeks. Our findings indicate that administration of Seroxat alone or in combination with acupuncture/electroacupuncture can produce a significant effect in patients with primary unipolar depression. Furthermore, acupuncture/electroacupuncture has a rapid onset of therapeutic effect and produces a noticeable improvement in obsessive-compulsive, depressive and anxiety symptoms.
【Fund】: supported by the National Science and Technology Support Program of China No.2006BAI12B05-2;; the National Natural Science Foundation of China No.30672768;; Key Discipline Construction Project of“211 Project”of Guangdong Province in China
【CateGory Index】: R246
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