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A Study on the Effect and Mechanism of Acupuncture Suppression of Neuronal Apoptosis Following Cerebral Ischemia

SHI Jing (Department of Neurobiology, Tongji Medical University, Wuhan 430030)  
On the basis of affirming that acupuncture suppresses neuronal apoptosis following cerebral ischemia, this study investigates the mechanism of acupuncture which modulates the intrinsic factors suppressing and promoting apoptosis. The main results showed that:(1) the symptom of neral defect induced by cerebral ischemia was improved and the area of infarction following cerebra ischemia was reduced after acupuncture treatment; (2) by employing PI and TUNEL staining, the apoptosis neurons were observed following cerebral ischemia, and acupuncture was able to protect against neuronal apoptosis following cerebral ischemia; (3) using a kinetic cadmium reduction method for the determination of nitric oxide (NO) and an immunohistochemistry method for observation of NOS immunoactivity in rat brain, it was found that the content of NO in the side of infarction was higher than that of control, and the increase of NO content was positively related to iNOS immunoactivity; acupuncture could inhibit iNOS activity thereby decreasing the NO level; (4) in situ hybridization study revealed that excitotoxicity of glutamate following cerebral ischemia was mediated by NMDAR1mRNA overexpression, that was down regulated by acupuncture; (5) immunohistochemistry study revealed that the expression of nerve growth factor receptor(trk A) was induced by acupuncture after cerebral ischemia, which may play a role in antagonizing apoptosis.
【CateGory Index】: R245-0
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Chinese Journal Full-text Database 10 Hits
1 ZHANG Zhi-Ying, YU An-Shen, YAN Zhen-Guo (Anatomy Department, Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032);Effect of electro-acupuncture on expression of caspase-3 mRNA and protein at early spinal cord injury in rats[J];Chinese Journal of Anatomy;2002-06
2 YANG Jing-li,MA Guo-ping,LIU Ju-ying,et al.Taihe Hospital of Yunyang Medical College,Shiyan,Hubei 442000,China;Effects of electroacfupuncture combined with intraperitoneal ketamine on expression of neuronal apoptosis in spinal cord in rats with chronic neuropathic pain.[J];Sichuan Medical Journal;2008-12
3 LIU Xin 1,DAI Ai guo 2, ZHOU Ji peng 1, ZHOU Jin ju 3,ZHAO Qiang 1, FAN Tian hui 1. 1.The First Hospital Affiliated to Nanhua University, Hengyang 421001,China; 2.The Third Hospital Affiliated to Nanhua University, Hengyang 421000, China; 3.The Second People's Hospital of Hengnan county, Hunan 421100, China);Effect of Acupuncture on Apoptosis of Pulmonary Eosinophile in Asthmatic Guinea-pigs[J];Shanghai Journal of Acupuncture and Moxibustion;2003-07
4 Mingshan Wang, Fuguo Ma, Huailong Chen Department of Anesthesiology, East District of Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China;Protective effects of acupuncture on brain tissue following ischemia/reperfusion injury[J];中国神经再生研究(英文版);2008-03
5 ZHENG Guo-qing, FANG Zhen-cong, WANG Ming-jie 1 (Guangzhou University of TCM, Guangzhou,510405; 1The Second Hospital Affiliated to Luzhou Medical College, Luzhou, 646000);Ideas and Methods for Experimental Research on Treatment of Stroke with Scalp-acupuncture[J];Acupuncture Research;2003-04
6 Pei Haitao, Guo Zhuangli (Affiliated Hospital of Medical Coll ege, Qingdao University, Shandong 266003, China);Effects of scalp-acupuncture on TGF-β_1mRNA expression in brain of the rat of focal cerebral ischemia-reperfusion[J];Chinese Acupuncture & Moxibustion;2003-12
7 ZENG Yan, LIANG Xun-chang (Department of Neurobiology of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China);Approach to central mechanisms of acupuncture actions by functional brain imaging[J];Chinese Acupuncture & Moxibustion;2004-02
8 WANG Wei, ZHU Fang, QI Jianpin, XIA Yeling, XIA Liming, WANG Chengyuan Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Comparison study of human brain response to acupuncture stimulation vs finger tapping task by using real time fMRI[J];Chinese Journal of Radiology;2002-03
9 CHEN Wen-jun~* SHOU Yi-qun LI Jian-hua XU Zhi-sheng LIU Hai *Department of Rehabilitation,Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou 310016,China;The effect of acupuncture at the acupoint Sanyinjiao on brain function as revealed by the functional magnetic resonance imaging[J];Chinese Journal of Physical Medicine and Rehabilitation;2007-11
10 FENG Yuan,HU You-ping;Research Generalization of Acupuncture Therapy of spastic limbs patient with Cerebral Apoplexy[J];Journal of Clinical Acupuncture and Moxibustion;2006-02
China Proceedings of conference Full-text Database 1 Hits
1 SHAO Cuang-rui, LIU Cheng, WANG Guang-bin. Dept. of lmaging, The Second Hospital of Shandong University, Jinan 250033, China;Localizing the specific functional areas within the human brain of acupuncturing the acupointLIS (Weizhong) with functional PET-CT imaging[A];[C];2005
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Liu Jun Xiang Liang-bi Cheng Yu,et al.(Department of Orthopaedics,The General Hospital of Shenyang Military Area Command,Shenyang 110015,China);Effects of Three-dimensional Rectification Apparatus on the Inflammatory Cells and Airway Remodeling of Guinea Pigs[J];Chinese Journal of Medicinal Guide;2008-06
2 ZHANG Gui-feng,LAI Xin-sheng,TANG Chun-zhi,YANG Jun-jun,WANG Shu-xia,SHAN Bao-ci,ZENG Tong-jun,HUANG Yong.School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China;PET Cerebral Functional Imaging Study on Activation Effect of Brain with Needling in Waiguan (TE5)[J];Guangdong Medical Journal;2009-01
3 YIN Xiao-ping,ZHANG Man-qing,WANG Wei.Department of Neurology,Affiliated Hospital of Jiujiang University,Jiujiang 332001,China;A Combined Use of fMRI and DTI in Patients with Intracerebral Hemorrhage[J];Neural Injury and Functional Reconstruction;2008-01
4 Zhang Xuerong, Luo Xiaoling, Song Hui,et al. (Research institute of Snake Venom, Guangxi Medical University, Nanning 530021 China);EFFECT OF GUANGXI COBRA VENOM NERVE GROWTH FACTOR ON CELLULAR IMMUNE FUNCTIONS IN BRAIN TRAUMA RATS[J];Journal of Guangxi Medical University;2007-04
5 XIE Jie-ping (School of Acupuncture & Moxibustion, Beijing University of Chinese Medicine,Beijing 100029,China);The essence of acupuncture effects-allocation of life substance[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-10
6 HAO Hong 1), LI Ning 2) 1)Department of Pharmaceutics, the Ninth People's Hospital of Zhengzhou, Zhengzhou 450053 2)Department of Pharmaceutics, Henan Tumor Hospital, Zhengzhou 450003;Effects of NGF on neural cell apoptosis in neonatal hypoxia-ischemia rats[J];Journal of Zhengzhou University(Medical Sciences);2006-05
7 HUANG Yan,LIU Xin,ZHAO Jiang,et al(The First Affiliated Hosptial,Nanhua University,Hengyang,Hunan 421001,China);Effect of Acupuncture on Inflammatory Cell and Airway Remodeling in Asthmatis Guinea-pigs[J];Journal of Nanhua University(Medical Edition);2006-02
8 ZHEN Jun-ping,LIU Cheng,HE Jing-zhen,et al.Department of Radiology,The Second Affiliated Hospital of Shanxi Medical University,Taiyuan,030001,China.;The research of brain fMRI in acupuncture of KI in different time[J];Chinese Imaging Journal of Integrated Traditional and Western Medicine;2008-05
9 WANG Fang, PAN San-qiang, L Lai-qing, SU Bao-gui (Dept. of Anatomy, Medical College, Jinan University, Guangzhou 510632, China);Effect of electroacupuncture on the expression of NOS-positive neurons of cerebral infarction rat[J];Journal of Jinan University(Natural Science & Medicine Edition);2004-04
10 Liu Dengtang,Jiang Kaida, Xu Yifeng, et al. Department of Psychiatry, Hua Shan Hospital, Shanghai Medical School of Fu Dan University, Shanghai 200030;Functional magnctk resonance imaging study in first-episode schizophrenic patients[J];Shanghai Archives of Psychiatry;2002-04
China Proceedings of conference Full-text Database 1 Hits
1 SHAO Cuang-rui, LIU Cheng, WANG Guang-bin. Dept. of lmaging, The Second Hospital of Shandong University, Jinan 250033, China;Localizing the specific functional areas within the human brain of acupuncturing the acupointLIS (Weizhong) with functional PET-CT imaging[A];[C];2005
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