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《Progress In Physiological Sciences》 2001-02
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Peroxynitrite-Mediated Pulmonary Vascular Injury Induced by Endotoxin and the Protective Role of Cholecystokinin

GU Zhen Yong (Department of Pathophysiology, Hebei Medical University, [WT5”BZ]Shijiazhuang 050017) [WT5HZ]  
WT5BZ] This study was to investigate the mediation of peroxynitrite(ONOO -) in pulmonary vascular injury induced by lipopolysaccharide(LPS),a major component of bacterial endotoxin, and the protective effect of cholecystokinin octapeptide(CCK) and its underlying mechanism. The generation of ONOO - in rat lungs was induced by administration of LPS (5mg/kg iv). Exogenous ONOO - led to increase in microvascular permeability and severe pathologic changes of rat lungs. The exposure of isolated pulmonary artery segment to ONOO - resulted in abnormal reactivities similar to those induced by LPS. ONOO - caused weak relaxation which was negatively regulated by endothelial cells.The significantly increased production of endogenous ONOO - in cultured BPAEC elicited by LPS might mediate cytotoxic effects of LPS. The protection of CCK against the effects of LPS in isolated pulmonary artery or BPAEC was mediated by CCK receptors and related to the inhibition of ONOO - generation. These data indicated that scavenging ONOO - or decreased in ONOO - generation provided a novel therapeutic strategy for alleviation of LPS induced pathologic process such as acute lung injury,and that CCK may be an endogenous cytoprotective factor for promising practice.
【Fund】: 国家自然科学基金!资助课题 (39870 317;;395 70 30 4)
【CateGory Index】: R363
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Chinese Journal Full-text Database 7 Hits
1 ;八肽胆囊收缩素对大鼠肺缺血再灌注损伤的保护作用[J];Contemporary Medicine;2009-09
2 GU Zhen Yong, LING Yi Ling , LI Shu Jin, MENG Ai Hong, ZHANG Jun Lan (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017);Properties of peroxynitrite-induced relaxation in rabbit pulmonary artery in vitro[J];Acta Physiological Sinica;2001-04
3 ZHANG Zhao-jian,LI Zhi-jun(Tianjin University of Chinese Medicine,Tianjin,300193,China);Clinical Observation of Treating Both Lung and Intestine on Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J];Shanxi Journal of Traditional Chinese Medicine;2009-10
4 LIANG Jun-qing,DING Chun-hua,LING Yi-ling,XU Hai-bo,LU-ping,XIAN Xiao-hui(Department of Pathophysiology of Hebei Medical University,Shijiazhuang 050017,China);THE PROTECTIVE FUNCTION OF PUERARIN TO THE INJURY OF THE LUNG AND IT'S MECHANISMS DURING DIABETES[J];Chinese Journal of Applied Physiology;2007-03
5 GAO Ju, ZENG Bang-xiong. Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Protective effects of prophylactic propofol on the lungs against acute injury induced by endotoxin in rats[J];Chinese Journal of Anesthesiology;2004-06
6 XUE Jin-rong, LIU Ying-long, WEN Fu-xing ,et al. Department of Congenital Defect, Cardiovascular Institute and Fuwai Hospital, CAMS and PUMC, Beijing 100037, China;The protective effect of cholecystokinin pulmonary perfusion during cardiopulmonary bypass on lung injury[J];Chinese Journal of Experimental Surgery;2004-09
7 GU Zhenyong 1,LING Yiling 1,WANG Xingyun 2,CONG Bin 1,ZHU Tienian 1. 1Department of Pathophysiology,Hebei Medical University,Shijiazhuang\ Hebei\ 050017;Inhibitory effect of cholecystokinin octapeptide on lipopolysaccharide-induced apoptosis of pulmonary artery endothelial cells[J];Chinese Critical Care Medicine;2001-12
Chinese Journal Full-text Database 1 Hits
Chinese Journal Full-text Database 10 Hits
1 LING Yi-ling,HUANG Xin-li(Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,China);Importance of the role of endogenous anti-shock material in shock[J];Journal of Traumatic Surgery;2008-03
2 XU Shun-Jiang,GAO Wei-Juan ,YAO Yu-Xia,GU Zhen-Yong ,CONG Bin (. Department of Pathophysiology,Hebei Medical University,Shijiazhuang 05007,China; 2. Hebei Center of Disease Control);Effect of lipopolysaccharides on expression of cholecystokinin receptor mRNA in rat pulmonary interstitial macrophages[J];Academic Journal of Second Military Medical University;2003-11
3 GAO Feng,GU Zhen-yong,PING Jing,LIU Xia,ZHAO Li,XU Jin-rong,NI Zhi-yu,CONG Bin,LING Yi-ling((Department) of Forensic Medicine, Heibei Medical University,Shijiazhuang 050017,China);Inhibitive effect of cholecystokinin octapeptide on iNOS expression induced by lipopolysaccharide in ECV-304[J];Acta Academiae Medicinae Militaris Tertiae;2006-19
4 MA Li-Qin, GU Zhen-Yong, DONG Guo-Kai, LI Na, GAO Feng, LIU Xia, MA Chun-Ling, CONG Bin, LING Yi-Ling Department of Forensic Medicine and Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China;Effect of cholecystokinin octapeptide on LPS-induced SOD mRNA expression and increase of NF-κB activity in rat vascular smooth muscle cells induced by LPS[J];Journal of the Fourth Military Medical University;2006-20
5 JIN Yu huai ,ZHAO Zhan sheng,XU Jin rong,LIU Pin li,LI Shu jin,LING Yi ling,CONG bin. Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,China Corresponding author:CONG bin,050017,Department of Pathophysiology,Hebei Medical University,Shijiazhuang,China;Effects of cholecystokinin octapeptide-8 on the proliferation of rat fibroblast-like synovial cells and its possible molecular mechanism[J];Chinese Journal of Rheumatology;2003-03
6 ZHAO Zhan sheng, JIN Yu huai, XU Jin rong, et al . (Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017, China);Effect of cholecystokinin octapeptide on IL-6 secretion by rat synovial cell line[J];Basic Medical Sciences and Clinics;2003-01
7 NI Zhi-yu, LI Shu-jin, CONG Bin, YAO Yu-xia, WANG Chun-yan(The School of Basic Medical Sciences,Hebei Medical University,Shijiazhuang 050017,China);Inhibitory effect of CCK-8 on the expressions of TLR4 and IL-1β in LPS-induced pulmonary interstitial macrophages of rats[J];Basic Medical Sciences and Clinics;2005-02
8 HAO Li-na ~(1),WANG Qiu-hong ~(1),LING Yi-ling ~(1),MENG Xiang-yan ~(1),ZHANG Xiao-jing ~(1),LIANG Jun-qing ~(1),XIAN Xiao-hui ~(1),HE Shou-zhi ~(2)(1.Department of Pathophysiology of Hebei Medical University,Shijiazhuang,050051;2.Department of Ophthalmology of P.L.A.General Hospital,Beijing,100866);Effect of cholecystokinin octapeptide on diabetic cataract of rats[J];Basic Medical Sciences and Clinics;2005-07
9 MENG Ai-Hong, LING Yi-Ling *, WANG Dian-Hua, GU Zhen-Yong, LI Shu-Jin, ZHU Tie-Nian (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017);Role of nitric oxide in cholecystokinin-octapeptide alleviation of tumor necrosis factor-alpha induced changes in rabbit pulmonary arterial reactivity[J];Acta Physiological Sinica;2001-06
10 MENG Ai Hong, LING Yi Ling *, ZHAO Xiao Yun, ZHANG Jun Lan, WANG Qiu Hong Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017;Inhibitory effect of cholecystokinin-octapeptide on production of cytokines in the lung of endotoxic shock rats[J];Acta Physiological Sinica;2002-02
Chinese Journal Full-text Database 10 Hits
1 LI Hong-yu,WANG Jiang-bin,JI Shang-wei;Risk analysis on diabetes mellitus and colorectal cancer[J];Journal of Jilin University(Medicine Edition);2007-02
2 Lu Changjun Li Ming,e Liu Junying,et al(Department of Respiratory,Affiliated Hospital,Binzhou Medical College,256603);ISOLATION AND CHARACTERIZATION OF INTERSTITIAL MACROPHAGES FROM RAT LUNG[J];JOURNAL OF BINZHOU MEDICAL COLLEGE;1998-01
3 Chen Huisun,Wang Jianghui,Diao Youfang et al (Research Institute of Field Surgery Third Military Medical College Chongqing, 630042);Injurious effects of free radicals on 5 organs and hepatic mitochondria during traumatic shock in rats[J];Acta Academiae Medicinae Militaris Tertiae;1992-03
4 KAI Li, HU De yao, LIU Liang ming (Research Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China);Modulation of opioid receptors on vascular hyporeactivity of rats after hemorrhagic shock[J];Acta Academiae Medicine Militaris Tertiae;2002-10
5 MA Li-Qin, GU Zhen-Yong, DONG Guo-Kai, LI Na, GAO Feng, LIU Xia, MA Chun-Ling, CONG Bin, LING Yi-Ling Department of Forensic Medicine and Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China;Effect of cholecystokinin octapeptide on LPS-induced SOD mRNA expression and increase of NF-κB activity in rat vascular smooth muscle cells induced by LPS[J];Journal of the Fourth Military Medical University;2006-20
6 (Guangdong Hospital of traditional Chinese medicine,Guangzhou,Guangdong 510120,China) HAN Yun,LIN Yan-zhao;TCM Clyster Combined with Non-invasive Ventilation in Treating for Respiratory Failure in Acute Exacerbations of COPD[J];Journal of Fujian College of Traditional Chinese Medicine;2006-02
7 FU Zhan li,WANG Rong fu (Department of Nuclear Medicine, The First Hospital of Beijing University, Beijing 100034,China);The influence of energy substrate environment on~(18)F-FDG imaging[J];Foreign Medical Science.radiomedicine and Nuclear Medicine;2000-02
8 CAO Jing xu, ZHANG Xu zhi (Department of Radiotherapy,PLA 210 Hospital,Liaoning Dalian 116021,China);Cytokines and radiation induced pulmonary injury[J];Foreign Medical Science.radiomedicine and Nuclear Medicine;2001-04
9 JI Mingli,QIAN Zhibin,Dpartment of pathophysiology,xinxiang medical collage,henan 453003 china);Effect of nitric oxide and peroxynitrite on ischemia-reperfusion injury of briain[J];Hainan Medical Journal;2002-02
10 Zhang Shilin, Yu Keli,Bi ping (Biology department,Tianjin Normal university)(Tianjin Friditional Chinese Medicinal Reserch Institute);The Change of NOS Activity in Lung Tissue and no Secreted by Alveolar Phagocyte after the Inchemia reperfusions in Rat′s small Intestine[J];STRAIT PHARMACEUTICAL JOURNAL;2000-02
【Secondary References】
Chinese Journal Full-text Database 8 Hits
1 YU Hai,LI Li,HE Li-ying(Department of Ophthalmology,Affiliated Second Hospital,Chongqing Medical University,Chongqing 400010,China);Protection effect of propofol on rabbit's lens oxidative stress[J];Laser Journal;2009-02
2 GU Zhen-Yong~1,2, LING Yi-Ling~2, XU Xiao-Hu~1, MENG Ai-Hong~2, LI Shu-Jin~2 1 Shantou University Medical College, Shantou 515031; 2 Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017;Effect of peroxynitrite on the reactivity of rabbit pulmonary arteries in vitro[J];Acta Physiological Sinica;2003-04
3 HUANG Xin-Li, LING Yi-Qun, ZHU Tie-Nian, ZHANG Jun-Lan, LING Yi-Ling Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China;Multiple factors contributing to lipopolysaccharide-induced reactivity changes in rabbit pulmonary artery[J];Acta Physiological Sinica;2005-06
4 LIU Dong, ZENG Bang-xiong , WANG Yue-lan, et al. Department of Anesthesiolagy, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022, China;Protective effects of pretreatment with rosiglitazone on the lungs against endotoxin-induced acute injury in rats[J];Chinese Journal of Anesthesiology;2005-10
5 GAO Ju,ZHAO Wei-xian,XIANG Dong-mei,et al.Department of Anedthesia,Second Affiliated Hospital of Guangzhou Traditional Chinese Medicine University,Guangzhou 510120,China;Effects of propofol on the expression of aquaporin-1 in lipopolysaccharide-activated rat lung microvessel endothelial cells[J];Chinese Journal of Critical Care Medicine;2006-09
6 YAN Jun,GU Zhenyong,WANG Xingyun,LIU Sen,XU Xiaohu,CONG Bin,LING Yiling.Department of Forensic Medicine and Pathophysiology,Hebei Medical University,Shijiazhuang 050017,Hebei,China(YAN Jun works at Department of Pathophysiology,Nankai Hospital,Tianjin 300100,China);Inhibitory effect of cholecystokinin octapeptide on lipopolysaccharide-elicited inducible nitric oxide synthase expression in vascular endothelial cells[J];Chinese Critical Care Medicine;2006-02
7 GAO Feng,GU Zhenyong,PING Jing,WANG Xingyun,LIU Xia, XU Jinrong,ZHAO Li,YAN Yuxian,MA Liqin,CONG Bin,LING Yiling.Department of Forensic Medicine and Pathophysiology,Shijiazhuang 050017,Hebei,China GAO Feng works at Department of Forensic Medicine,Public Security Bureau of Hebei Province,Shijiazhuang,Hebei,China);Receptor mechanisms underlying the modulation of lipopolysaccharide-induced nuclear factor-κB expression in vascular endothelial cells by cholecystokinin octapeptide[J];Chinese Critical Care Medicine;2006-03
8 LI Hong-chen(Dept. of Thoracic Surgery,Zhejiang Lanxi People's Hospital,Lanxi 321100,China) LIANG Gui-you,LIU Da-xing,LIU Bin(Dept. of Cardiovascular Thoracic Surgery,The Affiliated Hos-pital of Zunyi Medical College,Zunyi 563003,China);Protective Effects of Shenqi Fuzheng Injection on Ischemia Reperfusion Injury of the Lung in Dogs Following Cardiopulmonary Bypass[J];China Pharmacy;2009-36
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 MEI LIN;HAN JI-SHENG(Department of Physiology,Beijing Medical University,Beijing100083);CHOLECYSTOKININ-OCTAPEPTIDE ANTAGONIZES THE CENTRAL DEPRESSIVE EFFECT OF OPIOID PEPTIDES IN RATS[J];Acta Physiological Sinica;1991-02
2 Ling Yi-Ling, et al Department of Pathophysiology, Hebei Medical College, Shijiazhuang;The effect of naloxone on the electric activity of sympathetic nerve in rabbit SMAO shock[J];Chinese Journal of Pathophysiology;1986-02
3 Wang Le-Feng, Huang Shan-Sheng, et al Department of Pathophysiology, Medical College of Hebei, Shi jiazhuang;Clearance and detoxification of endotoxin by lung[J];Chinese Journal of Pathophysiology;1992-02
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