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《Acta Physiological Sinica》 1990-03
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EFFECT OF ENDOTHELIN ON THE RELEASE OF ANGIOTENSIN I FROM RAT CARDIOVASCULAR SYSTEM

BI WAN-LI;XIE XUAN-ZHU;WU JING;XU BAG-GANG;ZHAO QIU-YAN;Li ZHAO-PING;YU ZHONG-YUAN;TANG JIAN;TANG CHAO-SHU(Labaratory Cardiopulmonary Endocrinology,Beijing Medical University)  
The existence of angiotensin Ⅱ immunoreactive substance in rat cardiovascularsystem was demonstrated by RIA and immunohistochemistry techniques.In atrium,aorta and cultured rat aorta smooth muscle cells,angiotensin Ⅱcontent is 7.2+2.7pg/mg protein,152.4+59.2 pg/mg protein and 3.5+0.8pg/2×10~5 cells respectively.Endothelin,a potent vasoconstricting polypeptide,can enhance the release ofangiotensin Ⅱ from cultured rat aorta and aortic smooth muscle cells significantly.The results suggest that endothelin may be involved in the regulation of local bloodflow and vascular tone,and it may also implicate the pathogenesis of some cardiovas-cular diseases such as cardiohypertrophy and vascular hypertrophy.
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