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《Acta Physiological Sinica》 1991-02
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CHOLECYSTOKININ-OCTAPEPTIDE ANTAGONIZES THE CENTRAL DEPRESSIVE EFFECT OF OPIOID PEPTIDES IN RATS

MEI LIN;HAN JI-SHENG(Department of Physiology,Beijing Medical University,Beijing100083)  
Cholecystokinin-octapeptide(CCK-8)has been shown to antagonize the an-algesia produced by opioid peptides.The present study was performed to evaluateits effect on cardiovascular regulatory functions of opioids.Both CCK-8 and opioidpeptides were injected intrathecally(ith)in pentobarbital anaesthetized rats.Thedepressive effects induced by the mu agonist PL017(5 μg)delta agonist DADLE(25 μg)and kappa agonist 66A-078(1 μg)were antagonized by CCK-8 within adosage of 10μg in a dose dependent manner.CCK-8 can also partly antagonizethe bradycardiac effects induced by PL017,DADLE and 66A-078.The antagonistic effect of CCK-8 on DADLE in MAP could be reversed bypretreatment with CCK receptor antagonist proglumide(100μg).No significantchanges in MAP were found following ith administration of CCK-8 0.5-10μgand proglumide 100 μg,but a large dose(50μg)of CCK-8 lowered MAP dra-matically.The results suggest that within a certain range of dose CCK-8 in spinal cordmay play an antagonistic role against opioid effects in the regulation of cardio-vascular function and this effect of CCK-8 seems to be mediated by CCK recep-tor.These results support the hypothesis that CCK-8 may act as an anti-opioidsubstance in the CNS of the rat.
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